Gene description for LOC259246
Gene name alpha-2u globulin PGCL1
Gene symbol LOC259246
Other names/aliases Mup
Species Rattus norvegicus
 Database cross references - LOC259246
ExoCarta ExoCarta_259246
Entrez Gene 259246
UniProt P02761  
 LOC259246 identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for LOC259246
Molecular Function
    insulin-activated receptor activity GO:0005009 ISS
    small molecule binding GO:0036094 IEA
    transporter activity GO:0005215 IEA
    pheromone binding GO:0005550 ISS
Biological Process
    glucose homeostasis GO:0042593 ISS
    energy reserve metabolic process GO:0006112 ISS
    insulin receptor signaling pathway GO:0008286 ISS
    positive regulation of glucose metabolic process GO:0010907 ISS
    transport GO:0006810 IEA
    negative regulation of lipid biosynthetic process GO:0051055 ISS
    mitochondrion morphogenesis GO:0070584 ISS
    positive regulation of protein kinase B signaling GO:0051897 ISS
    heat generation GO:0031649 ISS
    positive regulation of lipid metabolic process GO:0045834 ISS
    negative regulation of lipid storage GO:0010888 ISS
    locomotor rhythm GO:0045475 ISS
    aerobic respiration GO:0009060 ISS
    cellular response to lipid GO:0071396 ISS
    negative regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061179 ISS
    negative regulation of transcription, DNA-templated GO:0045892 ISS
    positive regulation of gene expression GO:0010628 ISS
    negative regulation of gluconeogenesis GO:0045721 ISS
Subcellular Localization
    extracellular space GO:0005615 IDA
    cytosol GO:0005829 ISS
    nucleus GO:0005634 ISS
 Experiment description of studies that identified LOC259246 in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for LOC259246
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which LOC259246 is involved
No pathways found





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