Gene description for AOC1
Gene name amine oxidase, copper containing 1
Gene symbol AOC1
Other names/aliases ABP
ABP1
DAO
DAO1
KAO
Species Homo sapiens
 Database cross references - AOC1
ExoCarta ExoCarta_26
Entrez Gene 26
HGNC 80
MIM 104610
UniProt P19801  
 AOC1 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 25890246    
Colorectal cancer cells 25890246    
Urine 21082674    
 Gene ontology annotations for AOC1
Molecular Function
    propane-1,3-diamine oxidase activity GO:0052600 IEA
    calcium ion binding GO:0005509 IDA
    histamine oxidase activity GO:0052598 IEA
    protein complex binding GO:0032403 IDA
    quinone binding GO:0048038 IDA
    receptor activity GO:0004872 IDA
    zinc ion binding GO:0008270 IDA
    heparin binding GO:0008201 IDA
    cation channel activity GO:0005261 IDA
    methylputrescine oxidase activity GO:0052599 IEA
    sodium channel activity GO:0005272 TAS
    copper ion binding GO:0005507 IDA
    protein homodimerization activity GO:0042803 IPI
    diamine oxidase activity GO:0052597 IDA
    primary amine oxidase activity GO:0008131 IDA
    drug binding GO:0008144 IDA
Biological Process
    cellular response to azide GO:0097185 IDA
    amine metabolic process GO:0009308 IEA
    cellular response to histamine GO:0071420 IDA
    cellular response to copper ion GO:0071280 IDA
    response to antibiotic GO:0046677 IDA
    cellular response to copper ion starvation GO:0035874 IDA
    sodium ion transmembrane transport GO:0035725 TAS
    cellular response to heparin GO:0071504 TAS
    oxidation-reduction process GO:0055114 IDA
    response to drug GO:0042493 IDA
Subcellular Localization
    extracellular space GO:0005615 IDA
    plasma membrane GO:0005886 IDA
    peroxisome GO:0005777 NAS
    extracellular exosome GO:0070062 IDA
    bicellular tight junction GO:0005923 ISS
 Experiment description of studies that identified AOC1 in exosomes
1
Experiment ID 282
ISEV standards
CEM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81|EpCAM
EV Membrane markers
EV Negative markers
DLS
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors Xu R, Greening DW, Rai A, Ji H, Simpson RJ.
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Ultracentrifugation - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 283
ISEV standards
CEM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81|EpCAM
EV Membrane markers
EV Negative markers
DLS
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors Xu R, Greening DW, Rai A, Ji H, Simpson RJ.
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Ultracentrifugation - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
3
Experiment ID 102
ISEV standards
IEM
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21082674    
Organism Homo sapiens
Experiment description Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS.
Authors Zhang Y, Li Y, Qiu F, Qiu Z.
Journal name ELEC
Publication year 2010
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Immunoelectron Microscopy
 Protein-protein interactions for AOC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DNM2 1785
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which AOC1 is involved
No pathways found





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