Gene description for Cadm4
Gene name cell adhesion molecule 4
Gene symbol Cadm4
Other names/aliases Igdf4c
Igsf4c
Tsll2
Species Mus musculus
 Database cross references - Cadm4
ExoCarta ExoCarta_260299
Vesiclepedia VP_260299
Entrez Gene 260299
UniProt Q8R464  
 Cadm4 identified in sEVs derived from the following tissue/cell type
Melanoma cells 34957415    
Melanoma cells 34957415    
Melanoma cells 34957415    
 Gene ontology annotations for Cadm4
Molecular Function
    protein phosphatase binding GO:0019903 IPI
    receptor tyrosine kinase binding GO:0030971 IPI
    vascular endothelial growth factor receptor 1 binding GO:0043183 IPI
    vascular endothelial growth factor receptor 2 binding GO:0043184 IBA
    vascular endothelial growth factor receptor 2 binding GO:0043184 IPI
    vascular endothelial growth factor receptor 2 binding GO:0043184 ISO
Biological Process
    regulation of protein phosphorylation GO:0001932 IMP
    regulation of protein phosphorylation GO:0001932 ISO
    negative regulation of protein phosphorylation GO:0001933 IMP
    negative regulation of protein phosphorylation GO:0001933 ISO
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IBA
    negative regulation of peptidyl-threonine phosphorylation GO:0010801 IMP
    negative regulation of peptidyl-threonine phosphorylation GO:0010801 ISO
    negative regulation of vascular endothelial growth factor receptor signaling pathway GO:0030948 IMP
    regulation of Rac protein signal transduction GO:0035020 IBA
    regulation of Rac protein signal transduction GO:0035020 IMP
    regulation of Rac protein signal transduction GO:0035020 ISO
    regulation of cell population proliferation GO:0042127 IMP
    regulation of cell population proliferation GO:0042127 ISO
    negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 IMP
    negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 ISO
    regulation of wound healing GO:0061041 IBA
    regulation of wound healing GO:0061041 IMP
    regulation of wound healing GO:0061041 ISO
    synaptic membrane adhesion GO:0099560 IEA
    negative regulation of vascular endothelial growth factor signaling pathway GO:1900747 IMP
    regulation of cell motility GO:2000145 IMP
    regulation of cell motility GO:2000145 ISO
Subcellular Localization
    cell leading edge GO:0031252 ISO
    cell leading edge GO:0031252 ISS
    cell-cell contact zone GO:0044291 IBA
    cell-cell contact zone GO:0044291 ISO
    cell-cell contact zone GO:0044291 ISS
    synaptic membrane GO:0097060 IEA
 Experiment description of studies that identified Cadm4 in sEVs
1
Experiment ID 1101
MISEV standards
EM
Biophysical techniques
Cd81|Cd9|Tfrc|Gapdh|Lamp1
Enriched markers
GOLGA2|CANX
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 1102
MISEV standards
EM
Biophysical techniques
Cd81|Cd9|Tfrc|Gapdh|Lamp1
Enriched markers
GOLGA2|CANX
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F10
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
Flow cytometry
3
Experiment ID 1103
MISEV standards
EM
Biophysical techniques
Cd81|Cd9|Tfrc|Gapdh|Lamp1
Enriched markers
GOLGA2|CANX
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
Flow cytometry
 Protein-protein interactions for Cadm4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Sstr3  
Proximity Label-MS Mus musculus
View the network image/svg+xml
 Pathways in which Cadm4 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here