Gene description for Cops2
Gene name COP9 signalosome subunit 2
Gene symbol Cops2
Other names/aliases CSN2
Trip15
Species Rattus norvegicus
 Database cross references - Cops2
ExoCarta ExoCarta_261736
Vesiclepedia VP_261736
Entrez Gene 261736
UniProt P61203  
 Cops2 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Cops2
Molecular Function
    transcription corepressor activity GO:0003714 ISO
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    protein deneddylation GO:0000338 IBA
    protein deneddylation GO:0000338 ISO
    inner cell mass cell proliferation GO:0001833 ISO
    trophectodermal cell proliferation GO:0001834 ISO
    protein phosphorylation GO:0006468 ISO
    neuron differentiation GO:0030182 IDA
    skeletal muscle cell differentiation GO:0035914 ISO
    negative regulation of DNA-templated transcription GO:0045892 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    COP9 signalosome GO:0008180 IBA
    COP9 signalosome GO:0008180 ISO
 Experiment description of studies that identified Cops2 in sEVs
1
Experiment ID 95
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 98
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Cops2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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