Gene description for ND4
Gene name NADH dehydrogenase 4, mitochondrial
Gene symbol ND4
Other names/aliases -
Species Rattus norvegicus
 Database cross references - ND4
ExoCarta ExoCarta_26201
Entrez Gene 26201
UniProt P05508  
 ND4 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for ND4
Molecular Function
    molecular_function GO:0003674 ND
    NADH dehydrogenase (ubiquinone) activity GO:0008137 IEA
Biological Process
    cerebellum development GO:0021549 IEP
    mitochondrial electron transport, NADH to ubiquinone GO:0006120 IEA
    aging GO:0007568 IDA
    in utero embryonic development GO:0001701 IEP
    response to hypoxia GO:0001666 IEP
    response to ethanol GO:0045471 IEP
    response to nicotine GO:0035094 IEP
Subcellular Localization
    cellular_component GO:0005575 ND
    respiratory chain GO:0070469 IEA
    mitochondrial respiratory chain complex I GO:0005747 ISO
    integral component of membrane GO:0016021 IEA
    mitochondrion GO:0005739 ISO
    mitochondrial membrane GO:0031966 IEA
 Experiment description of studies that identified ND4 in exosomes
1
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for ND4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ND4 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here