Gene description for FBXO6
Gene name F-box protein 6
Gene symbol FBXO6
Other names/aliases FBG2
FBS2
FBX6
Fbx6b
Species Homo sapiens
 Database cross references - FBXO6
ExoCarta ExoCarta_26270
Vesiclepedia VP_26270
Entrez Gene 26270
HGNC 13585
MIM 605647
UniProt Q9NRD1  
 FBXO6 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for FBXO6
Molecular Function
    protein binding GO:0005515 IPI
    protein binding GO:0005515 ISS
    carbohydrate binding GO:0030246 IEA
    ubiquitin protein ligase activity GO:0061630 IBA
Biological Process
    DNA damage checkpoint signaling GO:0000077 TAS
    DNA repair GO:0006281 TAS
    proteolysis GO:0006508 TAS
    glycoprotein catabolic process GO:0006516 IBA
    response to unfolded protein GO:0006986 IEA
    protein ubiquitination GO:0016567 IEA
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 IBA
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 IDA
    ERAD pathway GO:0036503 IBA
    ERAD pathway GO:0036503 ISS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    SCF ubiquitin ligase complex GO:0019005 IBA
    SCF ubiquitin ligase complex GO:0019005 IDA
    endoplasmic reticulum quality control compartment GO:0044322 IBA
 Experiment description of studies that identified FBXO6 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FBXO6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ITGB1 3688
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 EIF3A 8661
Affinity Capture-MS Homo sapiens
3 SLC25A13 10165
Affinity Capture-MS Homo sapiens
4 NPEPPS 9520
Affinity Capture-MS Homo sapiens
5 ARHGEF2 9181
Affinity Capture-MS Homo sapiens
6 DNAJC11 55735
Affinity Capture-MS Homo sapiens
7 STT3A 3703
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 PRPF8 10594
Affinity Capture-MS Homo sapiens
9 PKM 5315
Affinity Capture-MS Homo sapiens
10 ACOT9 23597
Affinity Capture-MS Homo sapiens
11 NPC1 4864
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 GLB1 2720
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 DDX17 10521
Affinity Capture-MS Homo sapiens
14 SLC25A1 6576
Affinity Capture-MS Homo sapiens
15 CSE1L 1434
Affinity Capture-MS Homo sapiens
16 HEPH 9843
Affinity Capture-MS Homo sapiens
17 HIST1H4H 8365
Affinity Capture-MS Homo sapiens
18 TMEM126A 84233
Affinity Capture-MS Homo sapiens
19 GCN1L1 10985
Affinity Capture-MS Homo sapiens
20 PRKDC 5591
Affinity Capture-MS Homo sapiens
21 POMGNT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 FGFR3 2261
Affinity Capture-MS Homo sapiens
23 LAMC1 3915
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 IGF2BP3 10643
Affinity Capture-MS Homo sapiens
25 PFKL 5211
Affinity Capture-MS Homo sapiens
26 DPM1 8813
Affinity Capture-MS Homo sapiens
27 DARS 1615
Affinity Capture-MS Homo sapiens
28 ADGRG1 9289
Affinity Capture-MS Homo sapiens
29 GNS 2799
Affinity Capture-MS Homo sapiens
30 NAGA 4668
Affinity Capture-MS Homo sapiens
31 CDH2 1000
Affinity Capture-MS Homo sapiens
32 SEL1L 6400
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 TIMM23 100287932
Affinity Capture-MS Homo sapiens
34 HSPH1 10808
Affinity Capture-MS Homo sapiens
35 ABCD3 5825
Affinity Capture-MS Homo sapiens
36 HEXB 3074
Affinity Capture-MS Homo sapiens
37 PLBD2 196463
Affinity Capture-MS Homo sapiens
38 SMC2 10592
Affinity Capture-MS Homo sapiens
39 RPS9 6203
Affinity Capture-MS Homo sapiens
40 RPF2 84154
Affinity Capture-MS Homo sapiens
41 EIF3E 3646
Affinity Capture-MS Homo sapiens
42 SCARB1 949
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 COMT 1312
Affinity Capture-MS Homo sapiens
44 VPS4A 27183
Affinity Capture-MS Homo sapiens
45 ICAM4  
Affinity Capture-MS Homo sapiens
46 EEF1G 1937
Affinity Capture-MS Homo sapiens
47 COLGALT2  
Affinity Capture-MS Homo sapiens
48 GPS1 2873
Affinity Capture-MS Homo sapiens
49 MIR671  
Affinity Capture-MS Homo sapiens
50 FKBP10 60681
Affinity Capture-MS Homo sapiens
51 CCT5 22948
Affinity Capture-MS Homo sapiens
52 TFRC 7037
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
53 EEF1A1 1915
Affinity Capture-MS Homo sapiens
54 SLC25A3 5250
Affinity Capture-MS Homo sapiens
55 EMC1 23065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 RBMX 27316
Affinity Capture-MS Homo sapiens
57 PPM1B 5495
Affinity Capture-MS Homo sapiens
58 FARSA 2193
Affinity Capture-MS Homo sapiens
59 MAN2A2 4122
Affinity Capture-MS Homo sapiens
60 TMEM245 23731
Affinity Capture-MS Homo sapiens
61 NOMO1 23420
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 CMAS 55907
Affinity Capture-MS Homo sapiens
63 CAPZA1 829
Affinity Capture-MS Homo sapiens
64 RFC5 5985
Affinity Capture-MS Homo sapiens
65 PSMA4 5685
Affinity Capture-MS Homo sapiens
66 CNNM3 26505
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 CLU 1191
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 UGT8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 KIAA1161 57462
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 TMTC3 160418
Affinity Capture-MS Homo sapiens
71 TUFM 7284
Affinity Capture-MS Homo sapiens
72 COPB1 1315
Affinity Capture-MS Homo sapiens
73 PFKP 5214
Affinity Capture-MS Homo sapiens
74 ACP2 53
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 PABPC1 26986
Affinity Capture-MS Homo sapiens
76 CTSC 1075
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 TRIM21 6737
Affinity Capture-MS Homo sapiens
78 CKAP5 9793
Affinity Capture-MS Homo sapiens
79 PIGT 51604
Affinity Capture-MS Homo sapiens
80 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
81 FRAS1 80144
Affinity Capture-MS Homo sapiens
82 XPOT 11260
Affinity Capture-MS Homo sapiens
83 CYC1 1537
Affinity Capture-MS Homo sapiens
84 ENO1 2023
Affinity Capture-MS Homo sapiens
85 NDST2  
Affinity Capture-MS Homo sapiens
86 PIGS 94005
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 PLA2G15 23659
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 VDAC2 7417
Affinity Capture-MS Homo sapiens
89 SLC25A5 292
Affinity Capture-MS Homo sapiens
90 LRFN4  
Affinity Capture-MS Homo sapiens
91 MAP2K7 5609
Affinity Capture-MS Homo sapiens
92 SSR4 6748
Affinity Capture-MS Homo sapiens
93 TRIP13 9319
Affinity Capture-MS Homo sapiens
94 HSPA5 3309
Affinity Capture-MS Homo sapiens
95 EPDR1 54749
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 QSOX1 5768
Affinity Capture-MS Homo sapiens
97 HADHB 3032
Affinity Capture-MS Homo sapiens
98 LMNB1 4001
Affinity Capture-MS Homo sapiens
99 GGH 8836
Affinity Capture-MS Homo sapiens
100 PON2 5445
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 ATRN 8455
Affinity Capture-MS Homo sapiens
102 ERLEC1 27248
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 YWHAZ 7534
Affinity Capture-MS Homo sapiens
104 CLN5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 NAGLU 4669
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 LRRC47 57470
Affinity Capture-MS Homo sapiens
107 EPRS 2058
Affinity Capture-MS Homo sapiens
108 RBBP4 5928
Affinity Capture-MS Homo sapiens
109 HEXA 3073
Affinity Capture-MS Homo sapiens
110 PLXNA1 5361
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 PRMT5 10419
Affinity Capture-MS Homo sapiens
112 SNORD24  
Affinity Capture-MS Homo sapiens
113 PCBP1 5093
Affinity Capture-MS Homo sapiens
114 TMED10 10972
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 NME1 4830
Affinity Capture-MS Homo sapiens
116 TMCO1 54499
Affinity Capture-MS Homo sapiens
117 IGSF3 3321
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 HSPA1A 3303
Affinity Capture-MS Homo sapiens
119 NCLN 56926
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 PSMC5 5705
Affinity Capture-MS Homo sapiens
121 PVR 5817
Affinity Capture-MS Homo sapiens
122 ENTPD2 954
Affinity Capture-MS Homo sapiens
123 ILK 3611
Affinity Capture-MS Homo sapiens
124 SMC1A 8243
Affinity Capture-Western Homo sapiens
125 SLC25A6 293
Affinity Capture-MS Homo sapiens
126 HK2 3099
Affinity Capture-MS Homo sapiens
127 TTC13  
Affinity Capture-MS Homo sapiens
128 YBX1 4904
Affinity Capture-MS Homo sapiens
129 PPT1 5538
Affinity Capture-MS Homo sapiens
130 FASN 2194
Affinity Capture-MS Homo sapiens
131 NAAA  
Affinity Capture-MS Homo sapiens
132 CLPX 10845
Affinity Capture-MS Homo sapiens
133 WDR77 79084
Affinity Capture-MS Homo sapiens
134 LAMB3 3914
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
135 BMP3 651
Affinity Capture-MS Homo sapiens
136 RUVBL2 10856
Affinity Capture-MS Homo sapiens
137 EMC7 56851
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
138 CDC37 11140
Affinity Capture-MS Homo sapiens
139 SKP1 6500
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
140 TKT 7086
Affinity Capture-MS Homo sapiens
141 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
142 STK38L 23012
Affinity Capture-MS Homo sapiens
143 OS9 10956
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
144 TUT1  
Affinity Capture-MS Homo sapiens
145 SNORD36B  
Affinity Capture-MS Homo sapiens
146 OAT 4942
Affinity Capture-MS Homo sapiens
147 AGRN 375790
Affinity Capture-MS Homo sapiens
148 ATAD3A 55210
Affinity Capture-MS Homo sapiens
149 DDX3X 1654
Affinity Capture-MS Homo sapiens
150 ENPP3 5169
Affinity Capture-MS Homo sapiens
151 ITFG1 81533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
152 GAPDH 2597
Affinity Capture-MS Homo sapiens
153 ALYREF 10189
Affinity Capture-MS Homo sapiens
154 HNRNPL 3191
Affinity Capture-MS Homo sapiens
155 EIF4B 1975
Affinity Capture-MS Homo sapiens
156 ADAMTS7  
Affinity Capture-MS Homo sapiens
157 FECH 2235
Affinity Capture-MS Homo sapiens
158 TRIM28 10155
Affinity Capture-MS Homo sapiens
159 OLFM2  
Affinity Capture-MS Homo sapiens
160 LAMA5 3911
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
161 LDLR 3949
Affinity Capture-MS Homo sapiens
162 DNASE2 1777
Affinity Capture-MS Homo sapiens
163 COLGALT1 79709
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
164 NUP85 79902
Affinity Capture-MS Homo sapiens
165 SCAMP3 10067
Affinity Capture-MS Homo sapiens
166 HSPA1B 3304
Affinity Capture-MS Homo sapiens
167 PTGFRN 5738
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
168 PSMD3 5709
Affinity Capture-MS Homo sapiens
169 TENM4 26011
Affinity Capture-MS Homo sapiens
170 HNRNPH1 3187
Affinity Capture-MS Homo sapiens
171 EDEM1  
Affinity Capture-MS Homo sapiens
172 UGGT2 55757
Affinity Capture-MS Homo sapiens
173 LDHA 3939
Affinity Capture-MS Homo sapiens
174 AFG3L2 10939
Affinity Capture-MS Homo sapiens
175 SMC3 9126
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
176 SRPRB 58477
Affinity Capture-MS Homo sapiens
177 GART 2618
Affinity Capture-MS Homo sapiens
178 LAMP3  
Affinity Capture-MS Homo sapiens
179 IDUA 3425
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
180 TFB2M  
Affinity Capture-MS Homo sapiens
181 TARDBP 23435
Affinity Capture-MS Homo sapiens
182 PTPMT1 114971
Affinity Capture-MS Homo sapiens
183 ALB 213
Affinity Capture-MS Homo sapiens
184 SF3B1 23451
Affinity Capture-MS Homo sapiens
185 TTI1 9675
Affinity Capture-MS Homo sapiens
186 PROS1 5627
Affinity Capture-MS Homo sapiens
187 SPTLC1 10558
Affinity Capture-MS Homo sapiens
188 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
189 EIF4A1 1973
Affinity Capture-MS Homo sapiens
190 CDCP1 64866
Affinity Capture-MS Homo sapiens
191 GPR110  
Affinity Capture-MS Homo sapiens
192 COPA 1314
Affinity Capture-MS Homo sapiens
193 CPT1A 1374
Affinity Capture-MS Homo sapiens
194 LRP10 26020
Affinity Capture-MS Homo sapiens
195 RPS3 6188
Affinity Capture-MS Homo sapiens
196 ABCD1 215
Affinity Capture-MS Homo sapiens
197 LGALS3BP 3959
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
198 LRP1 4035
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
199 B3GNT2 10678
Affinity Capture-MS Homo sapiens
200 TUBB 203068
Affinity Capture-MS Homo sapiens
201 COPS6 10980
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
202 JMJD8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
203 CLEC2B  
Affinity Capture-MS Homo sapiens
204 SUSD1 64420
Affinity Capture-MS Homo sapiens
205 RFC3 5983
Affinity Capture-MS Homo sapiens
206 NPM1 4869
Affinity Capture-MS Homo sapiens
207 GCAT  
Affinity Capture-MS Homo sapiens
208 NUP93 9688
Affinity Capture-MS Homo sapiens
209 RUVBL1 8607