Gene description for FBXO6
Gene name F-box protein 6
Gene symbol FBXO6
Other names/aliases FBG2
FBS2
FBX6
Fbx6b
Species Homo sapiens
 Database cross references - FBXO6
ExoCarta ExoCarta_26270
Entrez Gene 26270
HGNC 13585
MIM 605647
UniProt Q9NRD1  
 FBXO6 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for FBXO6
Molecular Function
    carbohydrate binding GO:0030246 IEA
    glycoprotein binding GO:0001948 ISS
    protein binding GO:0005515 IPI
    ubiquitin-protein transferase activity GO:0004842 IEA
Biological Process
    DNA damage checkpoint GO:0000077 TAS
    proteolysis GO:0006508 TAS
    glycoprotein catabolic process GO:0006516 IEA
    protein ubiquitination GO:0016567 IEA
    ER-associated ubiquitin-dependent protein catabolic process GO:0030433 ISS
    DNA repair GO:0006281 TAS
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 IDA
    response to unfolded protein GO:0006986 IEA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    SCF ubiquitin ligase complex GO:0019005 IDA
 Experiment description of studies that identified FBXO6 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FBXO6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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