Gene description for Nr5a2
Gene name nuclear receptor subfamily 5, group A, member 2
Gene symbol Nr5a2
Other names/aliases AU020803
D1Ertd308e
Ftf
LRH-1
UF2-H3B
Species Mus musculus
 Database cross references - Nr5a2
ExoCarta ExoCarta_26424
Vesiclepedia VP_26424
Entrez Gene 26424
UniProt P45448  
 Nr5a2 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Nr5a2
Molecular Function
    transcription cis-regulatory region binding GO:0000976 ISO
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    transcription coregulator binding GO:0001221 IEA
    transcription coregulator binding GO:0001221 ISO
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
    DNA binding GO:0003677 IDA
    DNA binding GO:0003677 ISO
    chromatin binding GO:0003682 IDA
    double-stranded DNA binding GO:0003690 ISO
    DNA-binding transcription factor activity GO:0003700 ISO
    DNA-binding transcription factor activity GO:0003700 ISS
    nuclear receptor activity GO:0004879 IEA
    nuclear receptor activity GO:0004879 ISO
    phospholipid binding GO:0005543 IEA
    phospholipid binding GO:0005543 ISO
    zinc ion binding GO:0008270 IEA
    sequence-specific DNA binding GO:0043565 ISO
    sequence-specific double-stranded DNA binding GO:1990837 ISO
Biological Process
    regulation of DNA-templated transcription GO:0006355 ISO
    regulation of DNA-templated transcription GO:0006355 ISS
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    bile acid metabolic process GO:0008206 IMP
    hormone-mediated signaling pathway GO:0009755 IBA
    tissue development GO:0009888 IBA
    intracellular receptor signaling pathway GO:0030522 IEA
    regulation of cell population proliferation GO:0042127 IGI
    cholesterol homeostasis GO:0042632 IMP
    positive regulation of viral genome replication GO:0045070 IEA
    positive regulation of viral genome replication GO:0045070 ISO
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of DNA-templated transcription GO:0045893 ISO
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IGI
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    pancreas morphogenesis GO:0061113 IMP
    acinar cell differentiation GO:0090425 IMP
    calcineurin-mediated signaling GO:0097720 IEA
    calcineurin-mediated signaling GO:0097720 ISO
    cellular response to leukemia inhibitory factor GO:1990830 IEP
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 TAS
    RNA polymerase II transcription regulator complex GO:0090575 IBA
    RNA polymerase II transcription regulator complex GO:0090575 IDA
 Experiment description of studies that identified Nr5a2 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Nr5a2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Nr0b2  
Two-hybrid Mus musculus
2 Apc  
Phenotypic Suppression Mus musculus
3 Nr1h4  
Affinity Capture-Western Mus musculus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here