Gene description for Nr5a2
Gene name nuclear receptor subfamily 5, group A, member 2
Gene symbol Nr5a2
Other names/aliases AU020803
D1Ertd308e
Ftf
LRH-1
UF2-H3B
Species Mus musculus
 Database cross references - Nr5a2
ExoCarta ExoCarta_26424
Entrez Gene 26424
UniProt P45448  
 Nr5a2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Nr5a2
Molecular Function
    ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0004879 ISO
    sequence-specific DNA binding transcription factor activity GO:0003700 ISO
    zinc ion binding GO:0008270 IEA
    transcription regulatory region DNA binding GO:0044212 ISO
    phospholipid binding GO:0005543 ISO
    DNA binding GO:0003677 ISO
    metal ion binding GO:0046872 IEA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IDA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA
    steroid hormone receptor activity GO:0003707 IEA
    sequence-specific DNA binding GO:0043565 ISO
    double-stranded DNA binding GO:0003690 ISO
    lipid binding GO:0008289 IEA
Biological Process
    regulation of transcription from RNA polymerase II promoter GO:0006357 ISO
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP
    regulation of cell proliferation GO:0042127 IGI
    cholesterol homeostasis GO:0042632 IMP
    transcription, DNA-templated GO:0006351 IEA
    steroid hormone mediated signaling pathway GO:0043401 IEA
    positive regulation of transcription, DNA-templated GO:0045893 ISO
    positive regulation of viral genome replication GO:0045070 ISO
    epithelial cell differentiation GO:0030855 IMP
    bile acid metabolic process GO:0008206 IMP
    regulation of transcription, DNA-templated GO:0006355 ISO
    intracellular receptor signaling pathway GO:0030522 ISO
    pancreas morphogenesis GO:0061113 IMP
    transcription from RNA polymerase II promoter GO:0006366 IDA
Subcellular Localization
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Nr5a2 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Nr5a2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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