Gene description for GDF1
Gene name growth differentiation factor 1
Gene symbol GDF1
Other names/aliases DORV
DTGA3
RAI
Species Homo sapiens
 Database cross references - GDF1
ExoCarta ExoCarta_2657
Vesiclepedia VP_2657
Entrez Gene 2657
HGNC 4214
MIM 602880
UniProt P27539  
 GDF1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for GDF1
Molecular Function
    cytokine activity GO:0005125 IBA
    growth factor activity GO:0008083 IEA
Biological Process
    signal transduction GO:0007165 IEA
    negative regulation of cardiac muscle hypertrophy GO:0010614 IEA
Subcellular Localization
    extracellular space GO:0005615 IBA
 Experiment description of studies that identified GDF1 in sEVs
1
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for GDF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HTR4  
Two-hybrid Homo sapiens
2 CANX 821
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which GDF1 is involved
PathwayEvidenceSource
Developmental Biology IEA Reactome
Signaling by NODAL IEA Reactome





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