Gene description for GDF1
Gene name growth differentiation factor 1
Gene symbol GDF1
Other names/aliases DORV
DTGA3
RAI
Species Homo sapiens
 Database cross references - GDF1
ExoCarta ExoCarta_2657
Entrez Gene 2657
HGNC 4214
MIM 602880
UniProt P27539  
 GDF1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for GDF1
Molecular Function
    cytokine activity GO:0005125 IBA
    growth factor activity GO:0008083 IEA
    transforming growth factor beta receptor binding GO:0005160 IBA
Biological Process
    regulation of apoptotic process GO:0042981 IBA
    positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 IBA
    SMAD protein signal transduction GO:0060395 IBA
    cell development GO:0048468 IBA
    growth GO:0040007 IEA
    regulation of MAPK cascade GO:0043408 IBA
    BMP signaling pathway GO:0030509 IBA
Subcellular Localization
    extracellular space GO:0005615 IBA
 Experiment description of studies that identified GDF1 in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for GDF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which GDF1 is involved
PathwayEvidenceSource
Signaling by NODAL TAS Reactome





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