Gene description for Slc7a11
Gene name solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
Gene symbol Slc7a11
Other names/aliases 9930009M05Rik
AI451155
sut
xCT
Species Mus musculus
 Database cross references - Slc7a11
ExoCarta ExoCarta_26570
Entrez Gene 26570
UniProt Q9WTR6  
 Slc7a11 identified in exosomes derived from the following tissue/cell type
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Slc7a11
Molecular Function
    amino acid transmembrane transporter activity GO:0015171 IEA
    cystine:glutamate antiporter activity GO:0015327 IBA
Biological Process
    response to toxic substance GO:0009636 ISO
    transport GO:0006810 IEA
    modified amino acid transport GO:0072337 IBA
    platelet aggregation GO:0070527 IMP
    amino acid transport GO:0006865 IEA
    neutral amino acid transport GO:0015804 IBA
    amino acid transmembrane transport GO:0003333 IEA
    L-glutamate transmembrane transport GO:0089711 IBA
Subcellular Localization
    membrane GO:0016020 IEA
    cytoskeleton GO:0005856 ISO
    integral component of plasma membrane GO:0005887 IBA
    rough endoplasmic reticulum GO:0005791 ISO
    plasma membrane GO:0005886 ISO
    cell surface GO:0009986 ISO
    integral component of membrane GO:0016021 IEA
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Slc7a11 in exosomes
1
Experiment ID 214
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 215
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 216
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Slc7a11
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Slc7a11 is involved
PathwayEvidenceSource
Amino acid transport across the plasma membrane IEA Reactome
Basigin interactions IEA Reactome





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