Gene description for Lzts1
Gene name leucine zipper, putative tumor suppressor 1
Gene symbol Lzts1
Other names/aliases Psdzip70
Species Rattus norvegicus
 Database cross references - Lzts1
ExoCarta ExoCarta_266711
Entrez Gene 266711
UniProt Q8CFC9  
 Lzts1 identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Lzts1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    regulation of dendrite morphogenesis GO:0048814 IMP
    negative regulation of macroautophagy GO:0016242 ISO
    regulation of synaptic plasticity GO:0048167 NAS
Subcellular Localization
    postsynaptic membrane GO:0045211 IDA
    cell junction GO:0030054 IEA
    dendritic spine GO:0043197 IDA
    cytoplasm GO:0005737 IEA
    apical plasma membrane GO:0016324 IDA
    dendritic shaft GO:0043198 IDA
    neuron projection GO:0043005 IDA
    postsynaptic density GO:0014069 IDA
    cell body GO:0044297 IDA
    synapse GO:0045202 IDA
 Experiment description of studies that identified Lzts1 in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Lzts1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Lzts1 is involved
No pathways found





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