Gene description for Nlrc3
Gene name NLR family, CARD domain containing 3
Gene symbol Nlrc3
Other names/aliases CLR16.2
D230007K08Rik
mFLJ00348
Species Mus musculus
 Database cross references - Nlrc3
ExoCarta ExoCarta_268857
Vesiclepedia VP_268857
Entrez Gene 268857
UniProt Q5DU56  
 Nlrc3 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Nlrc3
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    phosphatidylinositol 3-kinase regulatory subunit binding GO:0036312 IDA
    molecular function inhibitor activity GO:0140678 IDA
Biological Process
    canonical NF-kappaB signal transduction GO:0007249 IMP
    canonical NF-kappaB signal transduction GO:0007249 ISO
    canonical NF-kappaB signal transduction GO:0007249 ISS
    regulation of protein ubiquitination GO:0031396 IDA
    regulation of protein ubiquitination GO:0031396 IMP
    negative regulation of NF-kappaB transcription factor activity GO:0032088 ISO
    response to lipopolysaccharide GO:0032496 IMP
    negative regulation of interferon-alpha production GO:0032687 IMP
    negative regulation of interferon-beta production GO:0032688 IMP
    negative regulation of interleukin-1 beta production GO:0032691 IMP
    negative regulation of interleukin-12 production GO:0032695 IMP
    negative regulation of interleukin-6 production GO:0032715 IMP
    negative regulation of interleukin-6 production GO:0032715 ISO
    negative regulation of tumor necrosis factor production GO:0032720 IMP
    negative regulation of tumor necrosis factor production GO:0032720 ISO
    T cell activation GO:0042110 ISS
    negative regulation of canonical NF-kappaB signal transduction GO:0043124 IBA
    negative regulation of canonical NF-kappaB signal transduction GO:0043124 IDA
    negative regulation of canonical NF-kappaB signal transduction GO:0043124 IGI
    negative regulation of canonical NF-kappaB signal transduction GO:0043124 IMP
    negative regulation of canonical NF-kappaB signal transduction GO:0043124 ISO
    negative regulation of innate immune response GO:0045824 IMP
    negative regulation of fibroblast proliferation GO:0048147 IMP
    negative regulation of epithelial cell proliferation GO:0050680 IMP
    negative regulation of inflammatory response GO:0050728 IMP
    negative regulation of inflammatory response GO:0050728 ISO
    negative regulation of inflammatory response GO:0050728 ISS
    negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 IMP
    negative regulation of cytokine production involved in inflammatory response GO:1900016 IMP
    negative regulation of NLRP3 inflammasome complex assembly GO:1900226 ISO
    negative regulation of NLRP3 inflammasome complex assembly GO:1900226 ISS
    negative regulation of non-canonical NF-kappaB signal transduction GO:1901223 ISO
    negative regulation of non-canonical NF-kappaB signal transduction GO:1901223 ISS
Subcellular Localization
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 IBA
    cytosol GO:0005829 ISO
    centriolar satellite GO:0034451 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    perinuclear region of cytoplasm GO:0048471 ISS
 Experiment description of studies that identified Nlrc3 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Nlrc3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Nlrc3 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here