Gene description for Ell3
Gene name elongation factor RNA polymerase II-like 3
Gene symbol Ell3
Other names/aliases A930015D22Rik
Species Mus musculus
 Database cross references - Ell3
ExoCarta ExoCarta_269344
Vesiclepedia VP_269344
Entrez Gene 269344
UniProt Q80VR2  
 Ell3 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ell3
Molecular Function
    cis-regulatory region sequence-specific DNA binding GO:0000987 IBA
    cis-regulatory region sequence-specific DNA binding GO:0000987 IDA
    protein binding GO:0005515 IPI
Biological Process
    DNA-templated transcription elongation GO:0006354 ISO
    transcription by RNA polymerase II GO:0006366 IMP
    transcription elongation by RNA polymerase II GO:0006368 IEA
    transcription elongation by RNA polymerase II GO:0006368 ISO
    regulation of epithelial to mesenchymal transition GO:0010717 IMP
    positive regulation of DNA-templated transcription, elongation GO:0032786 IEA
    positive regulation of DNA-templated transcription, elongation GO:0032786 ISO
    positive regulation of transcription elongation by RNA polymerase II GO:0032968 IBA
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 IMP
    snRNA transcription by RNA polymerase II GO:0042795 IBA
    snRNA transcription by RNA polymerase II GO:0042795 ISO
    snRNA transcription by RNA polymerase II GO:0042795 ISS
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    stem cell differentiation GO:0048863 IMP
    positive regulation of neurogenesis GO:0050769 IDA
    neural precursor cell proliferation GO:0061351 IDA
    stem cell proliferation GO:0072089 IDA
    signal transduction by p53 class mediator GO:0072331 IDA
    negative regulation of signal transduction by p53 class mediator GO:1901797 IDA
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 IMP
    positive regulation of neural precursor cell proliferation GO:2000179 IDA
    positive regulation of stem cell proliferation GO:2000648 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    chromosome GO:0005694 IEA
    chromosome GO:0005694 ISO
    nucleolus GO:0005730 IEA
    nucleolus GO:0005730 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    transcription elongation factor complex GO:0008023 IBA
    transcription elongation factor complex GO:0008023 ISO
    transcription elongation factor complex GO:0008023 ISS
    nuclear speck GO:0016607 IEA
    nuclear speck GO:0016607 ISO
    cell junction GO:0030054 IEA
    cell junction GO:0030054 ISO
 Experiment description of studies that identified Ell3 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ell3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Lama3  
Co-fractionation Mus musculus
2 Arhgap29  
Co-fractionation Mus musculus
View the network image/svg+xml



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