Gene description for Ell3
Gene name elongation factor RNA polymerase II-like 3
Gene symbol Ell3
Other names/aliases A930015D22Rik
Species Mus musculus
 Database cross references - Ell3
ExoCarta ExoCarta_269344
Entrez Gene 269344
UniProt Q80VR2  
 Ell3 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ell3
Molecular Function
    enhancer binding GO:0035326 IDA
    protein binding GO:0005515 IPI
Biological Process
    regulation of epithelial to mesenchymal transition GO:0010717 IMP
    positive regulation of neurogenesis GO:0050769 IDA
    regulation of transcription, DNA-templated GO:0006355 IEA
    positive regulation of neural precursor cell proliferation GO:2000179 IDA
    stem cell differentiation GO:0048863 IMP
    snRNA transcription from RNA polymerase II promoter GO:0042795 ISO
    transcription elongation from RNA polymerase II promoter GO:0006368 ISO
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 IMP
    negative regulation of signal transduction by p53 class mediator GO:1901797 IDA
    positive regulation of DNA-templated transcription, elongation GO:0032786 ISO
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    DNA-templated transcription, elongation GO:0006354 ISO
    transcription from RNA polymerase II promoter GO:0006366 IMP
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    nucleoplasm GO:0005654 ISO
    nucleolus GO:0005730 ISO
    transcription elongation factor complex GO:0008023 ISO
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Ell3 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ell3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ell3 is involved
No pathways found





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