Gene description for Rheb
Gene name	Ras homolog enriched in brain
Gene symbol	Rheb
Other names/aliases	-
Species	Rattus norvegicus
Database cross references - Rheb
ExoCarta	ExoCarta_26954
Vesiclepedia	VP_26954
Entrez Gene	26954
UniProt	Q62639
Rheb identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Rheb

Molecular Function     magnesium ion binding GO:0000287 IEA     magnesium ion binding GO:0000287 ISO     GTPase activity GO:0003924 IBA     GTPase activity GO:0003924 IDA     GTPase activity GO:0003924 IEA     GTPase activity GO:0003924 ISO     protein binding GO:0005515 IPI     GTP binding GO:0005525 IBA     GTP binding GO:0005525 IDA     GTP binding GO:0005525 IEA     GTP binding GO:0005525 ISO     GDP binding GO:0019003 IBA     GDP binding GO:0019003 IDA     GDP binding GO:0019003 IEA     GDP binding GO:0019003 ISO     protein kinase binding GO:0019901 IEA     protein kinase binding GO:0019901 ISO     protein kinase activator activity GO:0030295 ISO     protein kinase activator activity GO:0030295 ISS     protein serine/threonine kinase activator activity GO:0043539 IEA     protein serine/threonine kinase activator activity GO:0043539 ISO Biological Process     signal transduction GO:0007165 IEA     small GTPase-mediated signal transduction GO:0007264 IBA     small GTPase-mediated signal transduction GO:0007264 IDA     cellular response to nutrient levels GO:0031669 IEA     cellular response to nutrient levels GO:0031669 ISO     regulation of TOR signaling GO:0032006 ISO     positive regulation of TOR signaling GO:0032008 ISO     positive regulation of TOR signaling GO:0032008 ISS     regulation of neuronal synaptic plasticity GO:0048168 NAS     oligodendrocyte differentiation GO:0048709 IEA     oligodendrocyte differentiation GO:0048709 ISO     positive regulation of oligodendrocyte differentiation GO:0048714 IEA     positive regulation of oligodendrocyte differentiation GO:0048714 ISO     regulation of postsynapse organization GO:0099175 IDA     regulation of postsynapse organization GO:0099175 IMP     negative regulation of cold-induced thermogenesis GO:0120163 IEA     negative regulation of cold-induced thermogenesis GO:0120163 ISO     negative regulation of cold-induced thermogenesis GO:0120163 ISS     positive regulation of TORC1 signaling GO:1904263 IEA     positive regulation of TORC1 signaling GO:1904263 ISO     positive regulation of TORC1 signaling GO:1904263 ISS     regulation of type B pancreatic cell development GO:2000074 IEA     regulation of type B pancreatic cell development GO:2000074 ISO Subcellular Localization     Golgi membrane GO:0000139 IEA     Golgi membrane GO:0000139 ISO     spliceosomal complex GO:0005681 IEA     spliceosomal complex GO:0005681 ISO     lysosomal membrane GO:0005765 IEA     lysosomal membrane GO:0005765 ISO     lysosomal membrane GO:0005765 ISS     endoplasmic reticulum membrane GO:0005789 IEA     cytosol GO:0005829 IEA     plasma membrane GO:0005886 IBA     endomembrane system GO:0012505 IEA     endomembrane system GO:0012505 ISO     endomembrane system GO:0012505 ISS     postsynaptic density GO:0014069 IEA     postsynaptic density GO:0014069 ISO     membrane GO:0016020 IEA     dendrite GO:0030425 IDA     neuronal cell body GO:0043025 IDA     synapse GO:0045202 ISO     glutamatergic synapse GO:0098978 IDA     glutamatergic synapse GO:0098978 IMP