Gene description for Mthfd1l
Gene name methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
Gene symbol Mthfd1l
Other names/aliases 2410004L15Rik
AI647056
Fthfsdc1
Species Mus musculus
 Database cross references - Mthfd1l
ExoCarta ExoCarta_270685
Entrez Gene 270685
UniProt Q3V3R1  
 Mthfd1l identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Mthfd1l
Molecular Function
    ATP binding GO:0005524 ISO
    ligase activity GO:0016874 IEA
    protein homodimerization activity GO:0042803 ISO
    formate-tetrahydrofolate ligase activity GO:0004329 ISO
    nucleotide binding GO:0000166 IEA
    methylenetetrahydrofolate dehydrogenase (NADP+) activity GO:0004488 IEA
    catalytic activity GO:0003824 IEA
Biological Process
    folic acid-containing compound biosynthetic process GO:0009396 IEA
    one-carbon metabolic process GO:0006730 IBA
    10-formyltetrahydrofolate biosynthetic process GO:0009257 ISO
    formate metabolic process GO:0015942 ISO
    oxidation-reduction process GO:0055114 IEA
    tetrahydrofolate metabolic process GO:0046653 ISO
    folic acid-containing compound metabolic process GO:0006760 ISO
Subcellular Localization
    membrane GO:0016020 ISO
    mitochondrion GO:0005739 ISO
 Experiment description of studies that identified Mthfd1l in exosomes
1
Experiment ID 263
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th1 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Mthfd1l
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Mthfd1l is involved
No pathways found





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