Gene description for Pla2g7
Gene name phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
Gene symbol Pla2g7
Other names/aliases R75400
Species Mus musculus
 Database cross references - Pla2g7
ExoCarta ExoCarta_27226
Vesiclepedia VP_27226
Entrez Gene 27226
UniProt Q60963  
 Pla2g7 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Pla2g7
Molecular Function
    1-alkyl-2-acetylglycerophosphocholine esterase activity GO:0003847 IBA
    1-alkyl-2-acetylglycerophosphocholine esterase activity GO:0003847 ISO
    1-alkyl-2-acetylglycerophosphocholine esterase activity GO:0003847 ISS
    phospholipid binding GO:0005543 IEA
    phospholipid binding GO:0005543 ISO
    calcium-independent phospholipase A2 activity GO:0047499 ISO
    calcium-independent phospholipase A2 activity GO:0047499 ISS
Biological Process
    inflammatory response GO:0006954 TAS
    low-density lipoprotein particle remodeling GO:0034374 IEA
    low-density lipoprotein particle remodeling GO:0034374 ISO
    lipid oxidation GO:0034440 IEA
    lipid oxidation GO:0034440 ISO
    plasma lipoprotein particle oxidation GO:0034441 IEA
    plasma lipoprotein particle oxidation GO:0034441 ISO
    phosphatidylcholine catabolic process GO:0034638 ISO
    phosphatidylcholine catabolic process GO:0034638 ISS
    platelet activating factor metabolic process GO:0046469 ISO
    platelet activating factor metabolic process GO:0046469 ISS
    platelet activating factor catabolic process GO:0062234 ISO
    platelet activating factor catabolic process GO:0062234 ISS
    positive regulation of monocyte chemotaxis GO:0090026 IEA
    positive regulation of monocyte chemotaxis GO:0090026 ISO
Subcellular Localization
    extracellular space GO:0005615 ISO
    low-density lipoprotein particle GO:0034362 ISO
    low-density lipoprotein particle GO:0034362 ISS
    high-density lipoprotein particle GO:0034364 ISO
    high-density lipoprotein particle GO:0034364 ISS
 Experiment description of studies that identified Pla2g7 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Pla2g7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Arg1  
Co-fractionation Mus musculus
2 Mrps31  
Co-fractionation Mus musculus
3 Nrip1  
Co-fractionation Mus musculus
4 Trim24  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Pla2g7 is involved
PathwayEvidenceSource
Metabolism of proteins IEA Reactome
Peptide hormone metabolism IEA Reactome
Synthesis, secretion, and deacylation of Ghrelin IEA Reactome





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