Gene description for Dusp13
Gene name dual specificity phosphatase 13
Gene symbol Dusp13
Other names/aliases DUSP13A
DUSP13B
Gm1203
LMW-DSP6
MDSP
TMDP
TS-DSP6
Species Mus musculus
 Database cross references - Dusp13
ExoCarta ExoCarta_27389
Vesiclepedia VP_27389
Entrez Gene 27389
UniProt Q9QYJ7   Q6B8I0  
 Dusp13 identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Dusp13
Molecular Function
    non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IEA
    protein tyrosine/serine/threonine phosphatase activity GO:0008138 IBA
    protein tyrosine/serine/threonine phosphatase activity GO:0008138 IDA
    phosphatase activity GO:0016791 ISO
    myosin phosphatase activity GO:0017018 IEA
    protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA
    calmodulin-dependent protein phosphatase activity GO:0033192 IEA
    MAP kinase phosphatase activity GO:0033549 IBA
    histone H2AXS140 phosphatase activity GO:0140791 IEA
    histone H2AXY142 phosphatase activity GO:0140793 IEA
    RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity GO:0180004 IEA
    RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity GO:0180005 IEA
    RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity GO:0180006 IEA
    RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity GO:0180007 IEA
    RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity GO:0180008 IEA
    MAP kinase serine/threonine phosphatase activity GO:1990439 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    dephosphorylation GO:0016311 ISO
    negative regulation of MAPK cascade GO:0043409 IBA
Subcellular Localization
    cytoplasm GO:0005737 IBA
 Experiment description of studies that identified Dusp13 in sEVs
1
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Dusp13
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Dusp27  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Dusp13 is involved
No pathways found





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