Gene description for par-1
Gene name CG8201 gene product from transcript CG8201-RV
Gene symbol par-1
Other names/aliases 27C1
BcDNA:RH48823
CG11960
CG16701
CG30131
CG30132
CG8201
DPAR-1
DPar1
DmelCG8201
EMK
MARK
PAR-1
PAR1
PAR1/MARK2
Par-1
Par1
anon-WO0210402.19
dMARK
dPAR-1
dPAR1
dPar-1
dPar1
l(2)27C1
l(2)k06323
par1
Species Drosophila melanogaster
 Database cross references - par-1
ExoCarta ExoCarta_2768852
Vesiclepedia VP_2768852
Entrez Gene 2768852
 par-1 identified in sEVs derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for par-1
Molecular Function
    protein serine/threonine kinase activity GO:0004674 IDA
    protein serine/threonine kinase activity GO:0004674 ISS
    tau-protein kinase activity GO:0050321 IDA
Biological Process
    microtubule cytoskeleton organization GO:0000226 IMP
    establishment of imaginal disc-derived wing hair orientation GO:0001737 IMP
    germarium-derived oocyte fate determination GO:0007294 IMP
    border follicle cell migration GO:0007298 IMP
    oocyte anterior/posterior axis specification GO:0007314 IMP
    regulation of pole plasm oskar mRNA localization GO:0007317 IMP
    pole plasm protein localization GO:0007318 IMP
    axis specification GO:0009798 IMP
    oocyte microtubule cytoskeleton organization GO:0016325 IMP
    follicle cell of egg chamber development GO:0030707 IMP
    border follicle cell delamination GO:0030709 IMP
    regulation of polarized epithelial cell differentiation GO:0030860 IMP
    negative regulation of hippo signaling GO:0035331 IMP
    negative regulation of hippo signaling GO:0035331 IPI
    pole plasm oskar mRNA localization GO:0045451 TAS
    synaptic assembly at neuromuscular junction GO:0051124 IMP
    microtubule cytoskeleton organization involved in establishment of planar polarity GO:0090176 IMP
    positive regulation of border follicle cell migration GO:1903688 IMP
Subcellular Localization
    cell cortex GO:0005938 IDA
    basolateral plasma membrane GO:0016323 IDA
    neuromuscular junction GO:0031594 IDA
    fusome GO:0045169 IDA
    germline ring canal GO:0045172 IDA
    type I terminal bouton GO:0061174 IDA
 Experiment description of studies that identified par-1 in sEVs
1
Experiment ID 202
MISEV standards
IEM
Biophysical techniques
TSG10|RAB35|FLOT2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for par-1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Sln  
Two-hybrid Drosophila melanogaster
2 CG8173  
Two-hybrid Drosophila melanogaster
3 wdb  
Two-hybrid Drosophila melanogaster
4 ClC-b  
Two-hybrid Drosophila melanogaster
5 geminin  
Two-hybrid Drosophila melanogaster
6 nemy  
Two-hybrid Drosophila melanogaster
7 RpS27A  
Affinity Capture-Western Drosophila melanogaster
8 Mef2  
Two-hybrid Drosophila melanogaster
9 CkIIalpha  
Two-hybrid Drosophila melanogaster
10 Teh4  
Two-hybrid Drosophila melanogaster
11 slmb  
Affinity Capture-Western Drosophila melanogaster
12 CG6293  
Two-hybrid Drosophila melanogaster
13 NUCB1  
Two-hybrid Drosophila melanogaster
14 CG10616  
Two-hybrid Drosophila melanogaster
15 RhoGAP68F  
Two-hybrid Drosophila melanogaster
16 faf  
Negative Genetic Drosophila melanogaster
View the network image/svg+xml
 Pathways in which par-1 is involved
No pathways found





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