Gene description for par-1
Gene name CG8201 gene product from transcript CG8201-RV
Gene symbol par-1
Other names/aliases 27C1
BcDNA:RH48823
CG11960
CG16701
CG30131
CG30132
CG8201
DPAR-1
DPar1
DmelCG8201
EMK
MARK
PAR-1
PAR1
PAR1/MARK2
Par-1
Par1
anon-WO0210402.19
dMARK
dPAR-1
dPAR1
dPar-1
dPar1
l(2)27C1
l(2)k06323
par1
Species Drosophila melanogaster
 Database cross references - par-1
ExoCarta ExoCarta_2768852
Entrez Gene 2768852
 par-1 identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for par-1
Molecular Function
    ATP binding GO:0005524 IEA
    tau-protein kinase activity GO:0050321 IDA
    protein kinase activity GO:0004672 IDA
    protein serine/threonine kinase activity GO:0004674 NAS
Biological Process
    antimicrobial humoral response GO:0019730 IMP
    microtubule cytoskeleton organization GO:0000226 IMP
    oocyte nucleus localization involved in oocyte dorsal/ventral axis specification GO:0051663 IMP
    regulation of Wnt signaling pathway GO:0030111 TAS
    pole plasm oskar mRNA localization GO:0045451 TAS
    anterior/posterior axis specification GO:0009948 TAS
    oocyte differentiation GO:0009994 TAS
    synaptic growth at neuromuscular junction GO:0051124 IMP
    microtubule cytoskeleton organization involved in establishment of planar polarity GO:0090176 IMP
    pole plasm protein localization GO:0007318 IMP
    regulation of cell shape GO:0008360 IMP
    oocyte microtubule cytoskeleton organization GO:0016325 TAS
    axis specification GO:0009798 IMP
    protein phosphorylation GO:0006468 NAS
    actin filament organization GO:0007015 IMP
    positive regulation of hippo signaling GO:0035332 IPI
    gamete generation GO:0007276 IMP
    regulation of pole plasm oskar mRNA localization GO:0007317 IMP
    border follicle cell delamination GO:0030709 IMP
    negative regulation of protein phosphorylation GO:0001933 IDA
    establishment of imaginal disc-derived wing hair orientation GO:0001737 IMP
    germarium-derived oocyte fate determination GO:0007294 TAS
    ovarian follicle cell development GO:0030707 IMP
    maintenance of protein location GO:0045185 TAS
    border follicle cell migration GO:0007298 IMP
    oocyte anterior/posterior axis specification GO:0007314 TAS
Subcellular Localization
    cell cortex GO:0005938 IDA
    neuromuscular junction GO:0031594 IDA
    type I terminal bouton GO:0061174 IDA
    basolateral plasma membrane GO:0016323 IDA
    fusome GO:0045169 IDA
    germline ring canal GO:0045172 IDA
 Experiment description of studies that identified par-1 in exosomes
1
Experiment ID 202
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG10|RAB35
EV Cytosolic markers
✔
FLOT2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for par-1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which par-1 is involved
No pathways found





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