Gene description for F2
Gene name	coagulation factor II (thrombin)
Gene symbol	F2
Other names/aliases	-
Species	Bos taurus
Database cross references - F2
ExoCarta	ExoCarta_280685
Entrez Gene	280685
UniProt	P00735
F2 identified in exosomes derived from the following tissue/cell type
Milk	23459212
Serum	19327352

Gene ontology annotations for F2

Molecular Function     receptor binding GO:0005102 IEA     serine-type endopeptidase activity GO:0004252 IDA     fibrinogen binding GO:0070051 IPI     protein binding GO:0005515 IPI     thrombospondin receptor activity GO:0070053 IEA     calcium ion binding GO:0005509 IEA Biological Process     positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IEA     regulation of gene expression GO:0010468 IEA     positive regulation of collagen biosynthetic process GO:0032967 IEA     proteolysis GO:0006508 IDA     negative regulation of proteolysis GO:0045861 IEA     platelet activation GO:0030168 IEA     positive regulation of cell growth GO:0030307 IEA     positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 IEA     cell surface receptor signaling pathway GO:0007166 IEA     positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway GO:1900738 IEA     positive regulation of cell proliferation GO:0008284 IEA     positive regulation of reactive oxygen species metabolic process GO:2000379 IEA     regulation of cell shape GO:0008360 IEA     positive regulation of blood coagulation GO:0030194 IDA     acute-phase response GO:0006953 IEA     cytosolic calcium ion homeostasis GO:0051480 IEA     positive regulation of protein phosphorylation GO:0001934 IEA     protein polymerization GO:0051258 IDA     negative regulation of astrocyte differentiation GO:0048712 IEA     fibrinolysis GO:0042730 IEA Subcellular Localization     extracellular exosome GO:0070062 IEA     blood microparticle GO:0072562 IEA     cytosol GO:0005829 IEA