Gene description for F2
Gene name coagulation factor II (thrombin)
Gene symbol F2
Other names/aliases -
Species Bos taurus
 Database cross references - F2
ExoCarta ExoCarta_280685
Vesiclepedia VP_280685
Entrez Gene 280685
UniProt P00735  
 F2 identified in sEVs derived from the following tissue/cell type
Milk 23459212    
Serum 19327352    
 Gene ontology annotations for F2
Molecular Function
    serine-type endopeptidase activity GO:0004252 IEA
    calcium ion binding GO:0005509 IEA
Biological Process
    proteolysis GO:0006508 IEA
    blood coagulation GO:0007596 IEA
    platelet activation GO:0030168 IEA
    positive regulation of blood coagulation GO:0030194 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
    extracellular space GO:0005615 IEA
    collagen-containing extracellular matrix GO:0062023 IEA
 Experiment description of studies that identified F2 in sEVs
1
Experiment ID 213
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 187
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19327352    
Organism Bos taurus
Experiment description Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes.
Authors "Ochieng J, Pratap S, Khatua AK, Sakwe AM."
Journal name Exp Cell Res
Publication year 2009
Sample Serum
Sample name Normal - Fetal bovine serum
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for F2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which F2 is involved
No pathways found





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