Gene description for SERPINA1
Gene name serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Gene symbol SERPINA1
Other names/aliases PI
Species Bos taurus
 Database cross references - SERPINA1
ExoCarta ExoCarta_280699
Entrez Gene 280699
UniProt P34955  
 SERPINA1 identified in exosomes derived from the following tissue/cell type
Serum 19327352    
 Gene ontology annotations for SERPINA1
Molecular Function
    glycoprotein binding GO:0001948 IEA
    serine-type endopeptidase inhibitor activity GO:0004867 IBA
    identical protein binding GO:0042802 IEA
    protease binding GO:0002020 IEA
Biological Process
    negative regulation of endopeptidase activity GO:0010951 IBA
Subcellular Localization
    extracellular space GO:0005615 IBA
    Golgi apparatus GO:0005794 IEA
    endoplasmic reticulum GO:0005783 IEA
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified SERPINA1 in exosomes
1
Experiment ID 187
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19327352    
Organism Bos taurus
Experiment description Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes.
Authors Ochieng J, Pratap S, Khatua AK, Sakwe AM.
Journal name Exp Cell Res
Publication year 2009
Sample Serum
Sample name Normal - Fetal bovine serum
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SERPINA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SERPINA1 is involved
PathwayEvidenceSource
Platelet degranulation IEA Reactome





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