Gene description for AK1
Gene name adenylate kinase 1
Gene symbol AK1
Other names/aliases -
Species Bos taurus
 Database cross references - AK1
ExoCarta ExoCarta_280715
Entrez Gene 280715
UniProt P00570  
 AK1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for AK1
Molecular Function
    adenylate kinase activity GO:0004017 IEA
    ATP binding GO:0005524 IEA
    nucleoside diphosphate kinase activity GO:0004550 ISS
Biological Process
    AMP metabolic process GO:0046033 IEA
    nucleoside triphosphate biosynthetic process GO:0009142 ISS
    cell cycle arrest GO:0007050 IEA
    nucleoside diphosphate phosphorylation GO:0006165 ISS
    ADP biosynthetic process GO:0006172 IEA
    ATP metabolic process GO:0046034 IEA
Subcellular Localization
    plasma membrane GO:0005886 IEA
    extracellular exosome GO:0070062 IEA
    outer dense fiber GO:0001520 IEA
    sperm flagellum GO:0036126 IEA
 Experiment description of studies that identified AK1 in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for AK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which AK1 is involved
PathwayEvidenceSource
Synthesis and interconversion of nucleotide di- and triphosphates IEA Reactome





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