Gene description for B2M
Gene name beta-2-microglobulin
Gene symbol B2M
Other names/aliases -
Species Bos taurus
 Database cross references - B2M
ExoCarta ExoCarta_280729
Entrez Gene 280729
UniProt P01888  
 B2M identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for B2M
Molecular Function
    identical protein binding GO:0042802 IEA
Biological Process
    antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent GO:0002481 IEA
    T cell differentiation in thymus GO:0033077 IEA
    antigen processing and presentation of peptide antigen via MHC class I GO:0002474 IEA
    iron ion homeostasis GO:0055072 IEA
    response to molecule of bacterial origin GO:0002237 IEA
    protein refolding GO:0042026 IEA
    positive regulation of T cell mediated cytotoxicity GO:0001916 IEA
    retina homeostasis GO:0001895 IEA
Subcellular Localization
    external side of plasma membrane GO:0009897 IEA
    MHC class I protein complex GO:0042612 IEA
    extracellular space GO:0005615 IEA
    Golgi apparatus GO:0005794 IEA
    extracellular exosome GO:0070062 IEA
    focal adhesion GO:0005925 IEA
 Experiment description of studies that identified B2M in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for B2M
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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