Gene description for LTF
Gene name lactotransferrin
Gene symbol LTF
Other names/aliases Lf
Species Bos taurus
 Database cross references - LTF
ExoCarta ExoCarta_280846
Entrez Gene 280846
UniProt P24627  
 LTF identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for LTF
Molecular Function
    receptor binding GO:0005102 IMP
    iron ion binding GO:0005506 IEA
    serine-type endopeptidase activity GO:0004252 IEA
    protein serine/threonine kinase activator activity GO:0043539 IEA
    heparin binding GO:0008201 IEA
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of osteoclast development GO:2001205 IDA
    iron ion homeostasis GO:0055072 IEA
    antifungal humoral response GO:0019732 ISS
    innate immune response in mucosa GO:0002227 ISS
    negative regulation of apoptotic process GO:0043066 IDA
    regulation of cytokine production GO:0001817 ISS
    positive regulation of toll-like receptor 4 signaling pathway GO:0034145 IEA
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IEA
    negative regulation of tumor necrosis factor (ligand) superfamily member 11 production GO:2000308 IDA
    positive regulation of protein serine/threonine kinase activity GO:0071902 IEA
    negative regulation of lipopolysaccharide-mediated signaling pathway GO:0031665 ISS
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IEA
    positive regulation of bone mineralization involved in bone maturation GO:1900159 IDA
    negative regulation of single-species biofilm formation in or on host organism GO:1900229 ISS
    positive regulation of osteoblast proliferation GO:0033690 IDA
    retina homeostasis GO:0001895 IEA
    regulation of tumor necrosis factor production GO:0032680 ISS
    antibacterial humoral response GO:0019731 IDA
    positive regulation of osteoblast differentiation GO:0045669 ISS
    bone morphogenesis GO:0060349 ISS
    proteolysis GO:0006508 IEA
    ion transport GO:0006811 IEA
    positive regulation of chondrocyte proliferation GO:1902732 ISS
    ossification GO:0001503 IEA
Subcellular Localization
    extracellular space GO:0005615 IEA
    nucleus GO:0005634 IEA
    specific granule GO:0042581 ISS
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified LTF in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LTF
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which LTF is involved
No pathways found

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