Gene description for LUM
Gene name lumican
Gene symbol LUM
Other names/aliases -
Species Bos taurus
 Database cross references - LUM
ExoCarta ExoCarta_280847
Entrez Gene 280847
UniProt Q05443  
 LUM identified in exosomes derived from the following tissue/cell type
Serum 19327352    
 Gene ontology annotations for LUM
Molecular Function
    collagen binding GO:0005518 IEA
Biological Process
    visual perception GO:0007601 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA
    collagen fibril organization GO:0030199 IEA
Subcellular Localization
    extracellular space GO:0005615 IEA
    proteinaceous extracellular matrix GO:0005578 ISS
    extracellular exosome GO:0070062 IEA
    fibrillar collagen trimer GO:0005583 IEA
 Experiment description of studies that identified LUM in exosomes
1
Experiment ID 187
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19327352    
Organism Bos taurus
Experiment description Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes.
Authors Ochieng J, Pratap S, Khatua AK, Sakwe AM.
Journal name Exp Cell Res
Publication year 2009
Sample Serum
Sample name Normal - Fetal bovine serum
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LUM
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which LUM is involved
PathwayEvidenceSource
Integrin cell surface interactions IEA Reactome
Keratan sulfate biosynthesis IEA Reactome
Keratan sulfate degradation IEA Reactome





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