Gene description for MIF
Gene name macrophage migration inhibitory factor (glycosylation-inhibiting factor)
Gene symbol MIF
Other names/aliases -
Species Bos taurus
 Database cross references - MIF
ExoCarta ExoCarta_280858
Entrez Gene 280858
UniProt P80177  
 MIF identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for MIF
Molecular Function
    chemoattractant activity GO:0042056 IEA
    cytokine activity GO:0005125 IEA
    phenylpyruvate tautomerase activity GO:0050178 IEA
    cytokine receptor binding GO:0005126 IEA
    dopachrome isomerase activity GO:0004167 ISS
Biological Process
    positive regulation of prostaglandin secretion involved in immune response GO:0061078 IEA
    cell proliferation GO:0008283 IEA
    negative regulation of mature B cell apoptotic process GO:0002906 IEA
    negative regulation of cell aging GO:0090344 IEA
    positive regulation of peptidyl-serine phosphorylation GO:0033138 IEA
    positive regulation of lipopolysaccharide-mediated signaling pathway GO:0031666 IEA
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA
    positive regulation of MAP kinase activity GO:0043406 IEA
    positive regulation of B cell proliferation GO:0030890 IEA
    negative regulation of cell cycle arrest GO:0071157 IEA
    cell aging GO:0007569 IEA
    negative regulation of gene expression GO:0010629 IEA
    negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 IEA
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 IEA
    positive regulation of protein kinase A signaling GO:0010739 IEA
    negative regulation of cellular protein metabolic process GO:0032269 IEA
    prostaglandin biosynthetic process GO:0001516 IEA
    DNA damage response, signal transduction by p53 class mediator GO:0030330 IEA
    positive regulation of myeloid leukocyte cytokine production involved in immune response GO:0061081 IEA
    cell surface receptor signaling pathway GO:0007166 IEA
    innate immune response GO:0045087 IEA
    positive chemotaxis GO:0050918 IEA
    positive regulation of arachidonic acid secretion GO:0090238 IEA
    negative regulation of myeloid cell apoptotic process GO:0033033 IEA
    positive regulation of cytokine secretion GO:0050715 IEA
    positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 IEA
    protein homotrimerization GO:0070207 IEA
    inflammatory response GO:0006954 IEA
    positive regulation of fibroblast proliferation GO:0048146 IEA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    cell surface GO:0009986 IEA
    extracellular space GO:0005615 IEA
    nucleoplasm GO:0005654 IEA
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified MIF in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MIF
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MIF is involved
No pathways found





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