Gene description for RGN
Gene name regucalcin
Gene symbol RGN
Other names/aliases GNL
Species Bos taurus
 Database cross references - RGN
ExoCarta ExoCarta_280910
Entrez Gene 280910
UniProt Q9TTJ5  
 RGN identified in exosomes derived from the following tissue/cell type
Milk 23459212    
Serum 19327352    
 Gene ontology annotations for RGN
Molecular Function
    enzyme regulator activity GO:0030234 IEA
    calcium ion binding GO:0005509 ISS
    zinc ion binding GO:0008270 ISS
    gluconolactonase activity GO:0004341 ISS
Biological Process
    cellular calcium ion homeostasis GO:0006874 ISS
    positive regulation of ATPase activity GO:0032781 ISS
    L-ascorbic acid biosynthetic process GO:0019853 ISS
    regulation of calcium-mediated signaling GO:0050848 ISS
Subcellular Localization
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 ISS
    nucleoplasm GO:0005654 IEA
 Experiment description of studies that identified RGN in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 187
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19327352    
Organism Bos taurus
Experiment description Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes.
Authors Ochieng J, Pratap S, Khatua AK, Sakwe AM.
Journal name Exp Cell Res
Publication year 2009
Sample Serum
Sample name Normal - Fetal bovine serum
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RGN
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which RGN is involved
No pathways found





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