Gene description for VIM
Gene name vimentin
Gene symbol VIM
Other names/aliases -
Species Bos taurus
 Database cross references - VIM
ExoCarta ExoCarta_280955
Entrez Gene 280955
UniProt P48616  
 VIM identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for VIM
Molecular Function
    double-stranded RNA binding GO:0003725 IEA
    protein binding GO:0005515 IPI
    scaffold protein binding GO:0097110 IEA
    identical protein binding GO:0042802 IEA
    structural constituent of cytoskeleton GO:0005200 ISS
    glycoprotein binding GO:0001948 IEA
    protein C-terminus binding GO:0008022 IEA
    structural constituent of eye lens GO:0005212 IEA
Biological Process
    biological_process GO:0008150 ND
    intermediate filament organization GO:0045109 IEA
    astrocyte development GO:0014002 IEA
    in utero embryonic development GO:0001701 TAS
    SMAD protein signal transduction GO:0060395 IEA
    Bergmann glial cell differentiation GO:0060020 IEA
    negative regulation of neuron projection development GO:0010977 IEA
    lens fiber cell development GO:0070307 IEA
    positive regulation of gene expression GO:0010628 IEA
Subcellular Localization
    peroxisome GO:0005777 IEA
    cytosol GO:0005829 IEA
    cell leading edge GO:0031252 IEA
    extracellular exosome GO:0070062 IEA
    intermediate filament GO:0005882 ISS
    neuron projection GO:0043005 IEA
    cytoplasm GO:0005737 ISS
    plasma membrane GO:0005886 IEA
    focal adhesion GO:0005925 IEA
 Experiment description of studies that identified VIM in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for VIM
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which VIM is involved
PathwayEvidenceSource
Caspase-mediated cleavage of cytoskeletal proteins IEA Reactome
Striated Muscle Contraction IEA Reactome





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