Gene description for ALPL
Gene name alkaline phosphatase, liver/bone/kidney
Gene symbol ALPL
Other names/aliases TNS-AP
Species Bos taurus
 Database cross references - ALPL
ExoCarta ExoCarta_280994
Entrez Gene 280994
UniProt P09487  
 ALPL identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for ALPL
Molecular Function
    alkaline phosphatase activity GO:0004035 IDA
    pyrophosphatase activity GO:0016462 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    endochondral ossification GO:0001958 IEA
    osteoblast differentiation GO:0001649 IEA
    dephosphorylation GO:0016311 IEA
    biomineral tissue development GO:0031214 IDA
    response to antibiotic GO:0046677 IEA
    cellular response to organic cyclic compound GO:0071407 IEA
    developmental process involved in reproduction GO:0003006 IEA
    response to vitamin D GO:0033280 IEA
Subcellular Localization
    extracellular membrane-bounded organelle GO:0065010 IDA
    extracellular exosome GO:0070062 IEA
    extracellular matrix GO:0031012 IEA
    anchored component of membrane GO:0031225 IEA
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified ALPL in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ALPL
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ALPL is involved
No pathways found





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