Gene description for APOE
Gene name	apolipoprotein E
Gene symbol	APOE
Other names/aliases	-
Species	Bos taurus
Database cross references - APOE
ExoCarta	ExoCarta_281004
Entrez Gene	281004
UniProt	Q03247
APOE identified in exosomes derived from the following tissue/cell type
Milk	23459212
Serum	19327352

Gene ontology annotations for APOE

Molecular Function     lipoprotein particle binding GO:0071813 IEA     tau protein binding GO:0048156 IEA     low-density lipoprotein particle receptor binding GO:0050750 IEA     phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 IEA     heparin binding GO:0008201 IEA     cholesterol transporter activity GO:0017127 IEA     antioxidant activity GO:0016209 IEA     beta-amyloid binding GO:0001540 ISS     metal chelating activity GO:0046911 IEA     protein homodimerization activity GO:0042803 IEA     phospholipid binding GO:0005543 IEA     very-low-density lipoprotein particle receptor binding GO:0070326 IEA Biological Process     negative regulation of neuron death GO:1901215 IEA     positive regulation of neurofibrillary tangle assembly GO:1902998 IEA     cGMP-mediated signaling GO:0019934 IEA     positive regulation of presynaptic membrane organization GO:1901631 IEA     positive regulation of postsynaptic membrane organization GO:1901628 IEA     positive regulation of lipid transport across blood brain barrier GO:1903002 IEA     negative regulation of platelet activation GO:0010544 IEA     regulation of tau-protein kinase activity GO:1902947 IEA     G-protein coupled receptor signaling pathway GO:0007186 IEA     triglyceride metabolic process GO:0006641 IEA     protein import GO:0017038 IEA     reverse cholesterol transport GO:0043691 IEA     high-density lipoprotein particle clearance GO:0034384 IEA     alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering GO:0097113 IEA     cholesterol catabolic process GO:0006707 IEA     high-density lipoprotein particle assembly GO:0034380 IEA     negative regulation of dendritic spine maintenance GO:1902951 IEA     low-density lipoprotein particle remodeling GO:0034374 IEA     very-low-density lipoprotein particle remodeling GO:0034372 IEA     positive regulation of membrane protein ectodomain proteolysis GO:0051044 IEA     maintenance of location in cell GO:0051651 IEA     chylomicron remnant clearance GO:0034382 IEA     lipoprotein biosynthetic process GO:0042158 IEA     positive regulation of nitric-oxide synthase activity GO:0051000 IEA     positive regulation of low-density lipoprotein particle receptor catabolic process GO:0032805 IEA     fatty acid homeostasis GO:0055089 IEA     regulation of gene expression GO:0010468 IEA     vasodilation GO:0042311 IEA     positive regulation of cholesterol esterification GO:0010873 IEA     cellular calcium ion homeostasis GO:0006874 IEA     positive regulation of lipid biosynthetic process GO:0046889 IEA     response to oxidative stress GO:0006979 IEA     cholesterol efflux GO:0033344 IEA     response to dietary excess GO:0002021 IEA     positive regulation of cGMP biosynthetic process GO:0030828 IEA     negative regulation of beta-amyloid formation GO:1902430 IEA     N-methyl-D-aspartate receptor clustering GO:0097114 IEA     cholesterol homeostasis GO:0042632 IEA     nitric oxide mediated signal transduction GO:0007263 IEA     artery morphogenesis GO:0048844 IEA     negative regulation of MAP kinase activity GO:0043407 IEA     negative regulation of cholesterol biosynthetic process GO:0045541 IEA     negative regulation of endothelial cell proliferation GO:0001937 IEA     negative regulation of dendritic spine development GO:0061000 IEA     very-low-density lipoprotein particle clearance GO:0034447 IEA     positive regulation of cholesterol efflux GO:0010875 IEA     receptor-mediated endocytosis GO:0006898 IEA     regulation of beta-amyloid clearance GO:1900221 IEA     negative regulation of presynaptic membrane organization GO:1901630 IEA     positive regulation of phospholipid efflux GO:1902995 IEA     negative regulation of cholesterol efflux GO:0090370 IEA     negative regulation of lipid transport across blood brain barrier GO:1903001 IEA     positive regulation of neuron death GO:1901216 IEA     positive regulation of dendritic spine development GO:0060999 IEA     positive regulation of dendritic spine maintenance GO:1902952 IEA     regulation of Cdc42 protein signal transduction GO:0032489 IEA     negative regulation of inflammatory response GO:0050728 IEA     negative regulation of phospholipid efflux GO:1902999 IEA     phospholipid efflux GO:0033700 IEA     lipoprotein catabolic process GO:0042159 IEA     negative regulation of postsynaptic membrane organization GO:1901627 IEA     positive regulation of beta-amyloid formation GO:1902004 IEA     high-density lipoprotein particle remodeling GO:0034375 IEA     negative regulation of blood vessel endothelial cell migration GO:0043537 IEA     long-chain fatty acid transport GO:0015909 IEA Subcellular Localization     extracellular matrix GO:0031012 IEA     intermediate-density lipoprotein particle GO:0034363 IEA     high-density lipoprotein particle GO:0034364 IEA     chylomicron GO:0042627 IEA     membrane GO:0016020 IEA     blood microparticle GO:0072562 IEA     low-density lipoprotein particle GO:0034362 IEA     very-low-density lipoprotein particle GO:0034361 IEA     extracellular exosome GO:0070062 IEA     nucleus GO:0005634 IEA