Gene description for APOH
Gene name apolipoprotein H (beta-2-glycoprotein I)
Gene symbol APOH
Other names/aliases -
Species Bos taurus
 Database cross references - APOH
ExoCarta ExoCarta_281006
Entrez Gene 281006
UniProt P17690  
 APOH identified in exosomes derived from the following tissue/cell type
Milk 23459212    
Serum 19327352    
 Gene ontology annotations for APOH
Molecular Function
    lipoprotein lipase activator activity GO:0060230 IEA
    identical protein binding GO:0042802 IEA
    phospholipid binding GO:0005543 IEA
    heparin binding GO:0008201 IEA
    glycoprotein binding GO:0001948 IEA
Biological Process
    plasminogen activation GO:0031639 IEA
    positive regulation of lipoprotein lipase activity GO:0051006 IEA
    blood coagulation, intrinsic pathway GO:0007597 IEA
    negative regulation of fibrinolysis GO:0051918 IEA
    negative regulation of endothelial cell proliferation GO:0001937 IEA
    triglyceride metabolic process GO:0006641 IEA
    negative regulation of angiogenesis GO:0016525 IEA
    negative regulation of smooth muscle cell apoptotic process GO:0034392 IEA
    negative regulation of myeloid cell apoptotic process GO:0033033 IEA
    negative regulation of blood coagulation GO:0030195 IEA
    negative regulation of endothelial cell migration GO:0010596 IEA
Subcellular Localization
    very-low-density lipoprotein particle GO:0034361 IEA
    extracellular matrix GO:0031012 IEA
    extracellular exosome GO:0070062 IEA
    high-density lipoprotein particle GO:0034364 IEA
    chylomicron GO:0042627 IEA
    cell surface GO:0009986 IEA
 Experiment description of studies that identified APOH in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 187
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19327352    
Organism Bos taurus
Experiment description Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes.
Authors Ochieng J, Pratap S, Khatua AK, Sakwe AM.
Journal name Exp Cell Res
Publication year 2009
Sample Serum
Sample name Normal - Fetal bovine serum
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for APOH
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which APOH is involved
No pathways found





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