ExoCarta: Gene summary

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Gene description for CD14
Gene name	CD14 molecule
Gene symbol	CD14
Other names/aliases	-
Species	Bos taurus
Database cross references - CD14
ExoCarta	ExoCarta_281048
Vesiclepedia	VP_281048
Entrez Gene	281048
UniProt	Q95122
CD14 identified in sEVs derived from the following tissue/cell type
Milk	23459212

Gene ontology annotations for CD14

Molecular Function
	lipopolysaccharide binding	GO:0001530	IEA
	protein binding	GO:0005515	IEA
Biological Process
	inflammatory response	GO:0006954	IEA
	lipopolysaccharide-mediated signaling pathway	GO:0031663	IEA
	positive regulation of type I interferon production	GO:0032481	IEA
	positive regulation of type II interferon production	GO:0032729	IEA
	toll-like receptor 4 signaling pathway	GO:0034142	IEA
	positive regulation of non-canonical NF-kappaB signal transduction	GO:1901224	IEA
Subcellular Localization
	external side of plasma membrane	GO:0009897	IEA
	membrane raft	GO:0045121	IEA
	lipopolysaccharide receptor complex	GO:0046696	IEA

Experiment description of studies that identified CD14 in sEVs

Experiment ID

213

MISEV standards
✘	Biophysical techniques
✘	Enriched markers
✘	Negative markers
✘	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

23459212

Organism

Bos taurus

Experiment description

"Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."

Authors

"Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."

Journal name

J Proteomics

Publication year

2013

Sample

Milk

Sample name

Staphylococcus aureus-infected-Milk

Isolation/purification methods

Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Mass spectrometry

Protein-protein interactions for CD14

	Protein Interactor	ExoCarta ID	Identification method	PubMed	Species
No interactions are found.

Pathways in which CD14 is involved

Pathway	Evidence	Source
Activation of IRF3, IRF7 mediated by TBK1, IKKÎµ (IKBKE)	IEA	Reactome
Apoptosis	IEA	Reactome
Caspase activation via Death Receptors in the presence of ligand	IEA	Reactome
Caspase activation via extrinsic apoptotic signalling pathway	IEA	Reactome
IKK complex recruitment mediated by RIP1	IEA	Reactome
Immune System	IEA	Reactome
Innate Immune System	IEA	Reactome
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	IEA	Reactome
MyD88 dependent cascade initiated on endosome	IEA	Reactome
MyD88-independent TLR4 cascade	IEA	Reactome
Neutrophil degranulation	IEA	Reactome
Programmed Cell Death	IEA	Reactome
Regulation of TBK1, IKKÎµ (IKBKE)-mediated activation of IRF3, IRF7	IEA	Reactome
Regulation of TLR by endogenous ligand	IEA	Reactome
Toll Like Receptor 4 (TLR4) Cascade	IEA	Reactome
Toll Like Receptor 7/8 (TLR7/8) Cascade	IEA	Reactome
Toll Like Receptor 9 (TLR9) Cascade	IEA	Reactome
Toll-like Receptor Cascades	IEA	Reactome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	IEA	Reactome
TRAF6-mediated induction of TAK1 complex within TLR4 complex	IEA	Reactome
Transfer of LPS from LBP carrier to CD14	IEA	Reactome
TRIF (TICAM1)-mediated TLR4 signaling	IEA	Reactome
TRIF-mediated programmed cell death	IEA	Reactome

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