ExoCarta: Gene summary

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Gene description for CD36
Gene name	CD36 molecule (thrombospondin receptor)
Gene symbol	CD36
Other names/aliases	GPIIIB GPIV PAS-4
Species	Bos taurus
Database cross references - CD36
ExoCarta	ExoCarta_281052
Vesiclepedia	VP_281052
Entrez Gene	281052
UniProt	P26201
CD36 identified in sEVs derived from the following tissue/cell type
Milk	23459212

Gene ontology annotations for CD36

Molecular Function
	low-density lipoprotein particle receptor activity	GO:0005041	IEA
	scavenger receptor activity	GO:0005044	IEA
	low-density lipoprotein particle binding	GO:0030169	IEA
Biological Process
	receptor-mediated endocytosis	GO:0006898	IEA
	lipid storage	GO:0019915	IEA
	low-density lipoprotein particle clearance	GO:0034383	IEA
	lipoprotein transport	GO:0042953	IEA
	long-chain fatty acid import into cell	GO:0044539	IEA
	amyloid-beta clearance by cellular catabolic process	GO:0150094	IEA
Subcellular Localization
	cytoplasm	GO:0005737	IEA
	caveola	GO:0005901	IEA
	cell surface	GO:0009986	IEA

Experiment description of studies that identified CD36 in sEVs

Experiment ID

213

MISEV standards
✘	Biophysical techniques
✘	Enriched markers
✘	Negative markers
✘	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

23459212

Organism

Bos taurus

Experiment description

"Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."

Authors

"Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."

Journal name

J Proteomics

Publication year

2013

Sample

Milk

Sample name

Staphylococcus aureus-infected-Milk

Isolation/purification methods

Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Mass spectrometry

Protein-protein interactions for CD36

	Protein Interactor	ExoCarta ID	Identification method	PubMed	Species
No interactions are found.

Pathways in which CD36 is involved

Pathway	Evidence	Source
Adaptive Immune System	IEA	Reactome
Antigen processing-Cross presentation	IEA	Reactome
Binding and Uptake of Ligands by Scavenger Receptors	IEA	Reactome
Class I MHC mediated antigen processing & presentation	IEA	Reactome
Cross-presentation of particulate exogenous antigens (phagosomes)	IEA	Reactome
Free fatty acids regulate insulin secretion	IEA	Reactome
Hemostasis	IEA	Reactome
Immune System	IEA	Reactome
Innate Immune System	IEA	Reactome
Integration of energy metabolism	IEA	Reactome
Intracellular metabolism of fatty acids regulates insulin secretion	IEA	Reactome
Metabolism	IEA	Reactome
Neutrophil degranulation	IEA	Reactome
Platelet activation, signaling and aggregation	IEA	Reactome
Platelet degranulation	IEA	Reactome
Regulation of insulin secretion	IEA	Reactome
Regulation of TLR by endogenous ligand	IEA	Reactome
Response to elevated platelet cytosolic Ca2+	IEA	Reactome
Scavenging by Class B Receptors	IEA	Reactome
Toll-like Receptor Cascades	IEA	Reactome
Vesicle-mediated transport	IEA	Reactome

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