Gene description for CLTA
Gene name clathrin, light chain A
Gene symbol CLTA
Other names/aliases CLTA2
Species Bos taurus
 Database cross references - CLTA
ExoCarta ExoCarta_281078
Vesiclepedia VP_281078
Entrez Gene 281078
UniProt P04973  
 CLTA identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for CLTA
Molecular Function
    structural molecule activity GO:0005198 IEA
    clathrin heavy chain binding GO:0032050 IEA
Biological Process
    intracellular protein transport GO:0006886 IEA
    clathrin coat assembly GO:0048268 IEA
    clathrin-dependent endocytosis GO:0072583 IEA
Subcellular Localization
    plasma membrane GO:0005886 IEA
    clathrin coat of trans-Golgi network vesicle GO:0030130 IEA
    clathrin coat of coated pit GO:0030132 IEA
    synaptic vesicle membrane GO:0030672 IEA
    postsynaptic endocytic zone cytoplasmic component GO:0099631 IEA
 Experiment description of studies that identified CLTA in sEVs
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CLTA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Hip1r  
Reconstituted Complex Mus musculus
2 CLTC  
Reconstituted Complex Bos taurus
View the network image/svg+xml
 Pathways in which CLTA is involved
PathwayEvidenceSource
Adaptive Immune System IEA Reactome
Axon guidance IEA Reactome
Beta-catenin independent WNT signaling IEA Reactome
Cargo recognition for clathrin-mediated endocytosis IEA Reactome
Clathrin-mediated endocytosis IEA Reactome
Developmental Biology IEA Reactome
Formation of annular gap junctions IEA Reactome
Gap junction degradation IEA Reactome
Gap junction trafficking IEA Reactome
Gap junction trafficking and regulation IEA Reactome
Golgi Associated Vesicle Biogenesis IEA Reactome
Immune System IEA Reactome
L1CAM interactions IEA Reactome
LDL clearance IEA Reactome
Lysosome Vesicle Biogenesis IEA Reactome
Membrane Trafficking IEA Reactome
MHC class II antigen presentation IEA Reactome
Nervous system development IEA Reactome
PCP/CE pathway IEA Reactome
Plasma lipoprotein assembly, remodeling, and clearance IEA Reactome
Plasma lipoprotein clearance IEA Reactome
Recycling pathway of L1 IEA Reactome
Retrograde neurotrophin signalling IEA Reactome
Signal Transduction IEA Reactome
Signaling by NTRK1 (TRKA) IEA Reactome
Signaling by NTRKs IEA Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by WNT IEA Reactome
trans-Golgi Network Vesicle Budding IEA Reactome
Transport of small molecules IEA Reactome
Vesicle-mediated transport IEA Reactome
VLDLR internalisation and degradation IEA Reactome
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 IEA Reactome
WNT5A-dependent internalization of FZD4 IEA Reactome





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