Gene description for GART
Gene name phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
Gene symbol GART
Other names/aliases -
Species Bos taurus
 Database cross references - GART
ExoCarta ExoCarta_281183
Entrez Gene 281183
UniProt Q59A32  
 GART identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for GART
Molecular Function
    methyltransferase activity GO:0008168 IEA
    ATP binding GO:0005524 IEA
    phosphoribosylglycinamide formyltransferase activity GO:0004644 IEA
    phosphoribosylamine-glycine ligase activity GO:0004637 IEA
    phosphoribosylformylglycinamidine cyclo-ligase activity GO:0004641 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    purine nucleobase biosynthetic process GO:0009113 IEA
    methylation GO:0032259 IEA
    'de novo' IMP biosynthetic process GO:0006189 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified GART in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GART
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which GART is involved
PathwayEvidenceSource
Purine ribonucleoside monophosphate biosynthesis IEA Reactome





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