Gene description for GART
Gene name phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
Gene symbol GART
Other names/aliases -
Species Bos taurus
 Database cross references - GART
ExoCarta ExoCarta_281183
Entrez Gene 281183
UniProt Q59A32  
 GART identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for GART
Molecular Function
    methyltransferase activity GO:0008168 IEA
    ATP binding GO:0005524 IEA
    phosphoribosylglycinamide formyltransferase activity GO:0004644 IEA
    phosphoribosylamine-glycine ligase activity GO:0004637 IEA
    phosphoribosylformylglycinamidine cyclo-ligase activity GO:0004641 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    purine nucleobase biosynthetic process GO:0009113 IEA
    methylation GO:0032259 IEA
    'de novo' IMP biosynthetic process GO:0006189 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified GART in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GART
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which GART is involved
PathwayEvidenceSource
Purine ribonucleoside monophosphate biosynthesis IEA Reactome





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