Gene description for UBE2K
Gene name ubiquitin-conjugating enzyme E2K
Gene symbol UBE2K
Other names/aliases E2-25K
HIP2
HYPG
LIG
Species Bos taurus
 Database cross references - UBE2K
ExoCarta ExoCarta_281225
Entrez Gene 281225
UniProt P61085  
 UBE2K identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for UBE2K
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 ISS
    ATP binding GO:0005524 IEA
    ubiquitin protein ligase binding GO:0031625 ISS
    ligase activity GO:0016874 IEA
    ubiquitin conjugating enzyme activity GO:0061631 IDA
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin-ubiquitin ligase activity GO:0034450 IEA
Biological Process
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA
    protein K48-linked ubiquitination GO:0070936 ISS
    regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 IEA
    protein polyubiquitination GO:0000209 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 IBA
    actin cytoskeleton GO:0015629 IEA
    extracellular exosome GO:0070062 IEA
    intermediate filament cytoskeleton GO:0045111 IEA
 Experiment description of studies that identified UBE2K in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for UBE2K
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which UBE2K is involved
No pathways found





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