Gene description for HPRT1
Gene name hypoxanthine phosphoribosyltransferase 1
Gene symbol HPRT1
Other names/aliases HGPRT
Species Bos taurus
 Database cross references - HPRT1
ExoCarta ExoCarta_281229
Entrez Gene 281229
UniProt Q3SZ18  
 HPRT1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for HPRT1
Molecular Function
    magnesium ion binding GO:0000287 ISS
    protein homodimerization activity GO:0042803 ISS
    guanine phosphoribosyltransferase activity GO:0052657 ISS
    hypoxanthine phosphoribosyltransferase activity GO:0004422 ISS
    nucleotide binding GO:0000166 IEA
Biological Process
    IMP metabolic process GO:0046040 ISS
    hypoxanthine metabolic process GO:0046100 ISS
    positive regulation of dopamine metabolic process GO:0045964 ISS
    GMP salvage GO:0032263 IBA
    protein homotetramerization GO:0051289 ISS
    purine nucleotide biosynthetic process GO:0006164 ISS
    GMP catabolic process GO:0046038 ISS
    IMP salvage GO:0032264 IEA
    guanine salvage GO:0006178 ISS
    purine ribonucleoside salvage GO:0006166 ISS
    hypoxanthine salvage GO:0043103 ISS
    adenine salvage GO:0006168 IBA
Subcellular Localization
    cytosol GO:0005829 IBA
    cytoplasm GO:0005737 ISS
 Experiment description of studies that identified HPRT1 in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HPRT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which HPRT1 is involved
No pathways found

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