Gene description for IDH1
Gene name isocitrate dehydrogenase 1 (NADP+), soluble
Gene symbol IDH1
Other names/aliases -
Species Bos taurus
 Database cross references - IDH1
ExoCarta ExoCarta_281235
Entrez Gene 281235
UniProt Q9XSG3  
 IDH1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for IDH1
Molecular Function
    isocitrate dehydrogenase (NADP+) activity GO:0004450 ISS
    NAD binding GO:0051287 IEA
    magnesium ion binding GO:0000287 ISS
    protein homodimerization activity GO:0042803 IEA
    receptor binding GO:0005102 IEA
Biological Process
    response to oxidative stress GO:0006979 ISS
    tricarboxylic acid cycle GO:0006099 IEA
    2-oxoglutarate metabolic process GO:0006103 ISS
    glyoxylate cycle GO:0006097 IEA
    glutathione metabolic process GO:0006749 ISS
    isocitrate metabolic process GO:0006102 ISS
Subcellular Localization
    extracellular exosome GO:0070062 IEA
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 ISS
    mitochondrion GO:0005739 IEA
    peroxisome GO:0005777 IEA
 Experiment description of studies that identified IDH1 in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for IDH1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which IDH1 is involved
PathwayEvidenceSource
NADPH regeneration IEA Reactome





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