Gene description for LDHB
Gene name lactate dehydrogenase B
Gene symbol LDHB
Other names/aliases -
Species Bos taurus
 Database cross references - LDHB
ExoCarta ExoCarta_281275
Entrez Gene 281275
UniProt Q5E9B1  
 LDHB identified in exosomes derived from the following tissue/cell type
Milk 23459212    
Serum 19327352    
 Gene ontology annotations for LDHB
Molecular Function
    L-lactate dehydrogenase activity GO:0004459 IEA
Biological Process
    carboxylic acid metabolic process GO:0019752 IEA
    oxidation-reduction process GO:0055114 IEA
    carbohydrate metabolic process GO:0005975 IEA
Subcellular Localization
    membrane GO:0016020 IEA
    mitochondrion GO:0005739 IEA
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified LDHB in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 187
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19327352    
Organism Bos taurus
Experiment description Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes.
Authors Ochieng J, Pratap S, Khatua AK, Sakwe AM.
Journal name Exp Cell Res
Publication year 2009
Sample Serum
Sample name Normal - Fetal bovine serum
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LDHB
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which LDHB is involved
PathwayEvidenceSource
Pyruvate metabolism IEA Reactome





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