Gene description for SERPINF1
Gene name serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
Gene symbol SERPINF1
Other names/aliases PEDF
Species Bos taurus
 Database cross references - SERPINF1
ExoCarta ExoCarta_281386
Entrez Gene 281386
UniProt Q95121  
 SERPINF1 identified in exosomes derived from the following tissue/cell type
Serum 19327352    
 Gene ontology annotations for SERPINF1
Molecular Function
    serine-type endopeptidase inhibitor activity GO:0004867 IBA
Biological Process
    negative regulation of endopeptidase activity GO:0010951 IBA
    negative regulation of epithelial cell proliferation involved in prostate gland development GO:0060770 IEA
    negative regulation of angiogenesis GO:0016525 IEA
    positive regulation of neurogenesis GO:0050769 ISS
Subcellular Localization
    melanosome GO:0042470 IEA
    extracellular region GO:0005576 IDA
    extracellular matrix GO:0031012 IEA
    extracellular space GO:0005615 IBA
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified SERPINF1 in exosomes
1
Experiment ID 187
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19327352    
Organism Bos taurus
Experiment description Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes.
Authors Ochieng J, Pratap S, Khatua AK, Sakwe AM.
Journal name Exp Cell Res
Publication year 2009
Sample Serum
Sample name Normal - Fetal bovine serum
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SERPINF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SERPINF1 is involved
No pathways found





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