Gene description for PRNP
Gene name prion protein
Gene symbol PRNP
Other names/aliases AltPrP
PrP
Species Bos taurus
 Database cross references - PRNP
ExoCarta ExoCarta_281427
Entrez Gene 281427
UniProt F7VJQ2   P10279  
 PRNP identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PRNP
Molecular Function
    protein binding GO:0005515 IPI
    copper ion binding GO:0005507 ISS
    identical protein binding GO:0042802 IPI
    microtubule binding GO:0008017 IEA
Biological Process
    negative regulation of sequence-specific DNA binding transcription factor activity GO:0043433 IEA
    regulation of protein localization GO:0032880 IEA
    negative regulation of interferon-gamma production GO:0032689 IEA
    protein homooligomerization GO:0051260 IEA
    negative regulation of activated T cell proliferation GO:0046007 IEA
    negative regulation of interleukin-17 production GO:0032700 IEA
    regulation of potassium ion transmembrane transport GO:1901379 IEA
    negative regulation of T cell receptor signaling pathway GO:0050860 IEA
    cellular response to copper ion GO:0071280 IEA
    negative regulation of apoptotic process GO:0043066 IEA
    negative regulation of interleukin-2 production GO:0032703 IEA
    negative regulation of protein phosphorylation GO:0001933 IEA
    negative regulation of calcineurin-NFAT signaling cascade GO:0070885 IEA
    response to oxidative stress GO:0006979 IEA
Subcellular Localization
    plasma membrane GO:0005886 IEA
    endoplasmic reticulum GO:0005783 IEA
    extracellular exosome GO:0070062 IEA
    cell surface GO:0009986 IEA
    mitochondrial outer membrane GO:0005741 ISS
    integral component of membrane GO:0016021 IEA
    anchored component of membrane GO:0031225 IEA
    membrane raft GO:0045121 ISS
    Golgi apparatus GO:0005794 IEA
 Experiment description of studies that identified PRNP in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PRNP
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PRNP is involved
PathwayEvidenceSource
NCAM1 interactions IEA Reactome





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