Gene description for RAC1
Gene name ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Gene symbol RAC1
Other names/aliases -
Species Bos taurus
 Database cross references - RAC1
ExoCarta ExoCarta_281440
Vesiclepedia VP_281440
Entrez Gene 281440
UniProt P62998  
 RAC1 identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for RAC1
Molecular Function
    GTPase activity GO:0003924 IEA
    GTP binding GO:0005525 IEA
    protein kinase binding GO:0019901 IEA
Biological Process
    actin filament organization GO:0007015 IEA
    establishment or maintenance of cell polarity GO:0007163 IEA
    small GTPase-mediated signal transduction GO:0007264 IEA
    motor neuron axon guidance GO:0008045 IEA
    regulation of cell shape GO:0008360 IEA
    cortical cytoskeleton organization GO:0030865 IEA
    regulation of actin cytoskeleton organization GO:0032956 IEA
Subcellular Localization
    cytoskeleton GO:0005856 IEA
    plasma membrane GO:0005886 IEA
    cell cortex GO:0005938 IEA
    cytoplasmic vesicle GO:0031410 IEA
    dendritic spine GO:0043197 IEA
 Experiment description of studies that identified RAC1 in sEVs
1
Experiment ID 213
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RAC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which RAC1 is involved
No pathways found





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