Gene description for SOD1
Gene name superoxide dismutase 1, soluble
Gene symbol SOD1
Other names/aliases SOD1L1
Species Bos taurus
 Database cross references - SOD1
ExoCarta ExoCarta_281495
Entrez Gene 281495
UniProt P00442  
 SOD1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for SOD1
Molecular Function
    protein binding GO:0005515 IPI
    superoxide dismutase activity GO:0004784 ISS
    ubiquitin-protein transferase activity GO:0004842 ISS
    zinc ion binding GO:0008270 ISS
    protein phosphatase 2B binding GO:0030346 ISS
    copper ion binding GO:0005507 ISS
    chaperone binding GO:0051087 ISS
Biological Process
    muscle cell cellular homeostasis GO:0046716 ISS
    sensory perception of sound GO:0007605 ISS
    response to axon injury GO:0048678 ISS
    regulation of protein kinase activity GO:0045859 ISS
    transmission of nerve impulse GO:0019226 ISS
    hydrogen peroxide biosynthetic process GO:0050665 ISS
    positive regulation of catalytic activity GO:0043085 ISS
    double-strand break repair GO:0006302 ISS
    ovarian follicle development GO:0001541 ISS
    response to ethanol GO:0045471 ISS
    neurofilament cytoskeleton organization GO:0060052 ISS
    response to hydrogen peroxide GO:0042542 ISS
    myeloid cell homeostasis GO:0002262 ISS
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISS
    cell aging GO:0007569 ISS
    locomotory behavior GO:0007626 ISS
    negative regulation of cholesterol biosynthetic process GO:0045541 ISS
    response to superoxide GO:0000303 ISS
    protein polyubiquitination GO:0000209 ISS
    regulation of mitochondrial membrane potential GO:0051881 ISS
    activation of MAPK activity GO:0000187 ISS
    heart contraction GO:0060047 ISS
    cellular iron ion homeostasis GO:0006879 ISS
    superoxide metabolic process GO:0006801 ISS
    apoptotic DNA fragmentation GO:0006309 ISS
    auditory receptor cell stereocilium organization GO:0060088 ISS
    retina homeostasis GO:0001895 ISS
    removal of superoxide radicals GO:0019430 ISS
    spermatogenesis GO:0007283 ISS
    response to heat GO:0009408 ISS
    peripheral nervous system myelin maintenance GO:0032287 ISS
    negative regulation of neuron apoptotic process GO:0043524 ISS
    response to drug GO:0042493 ISS
    regulation of blood pressure GO:0008217 ISS
    relaxation of vascular smooth muscle GO:0060087 ISS
    glutathione metabolic process GO:0006749 ISS
    positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 IDA
    response to organic substance GO:0010033 ISS
    regulation of multicellular organism growth GO:0040014 ISS
    regulation of cytokine production GO:0001817 IDA
    positive regulation of cytokine production GO:0001819 ISS
    embryo implantation GO:0007566 ISS
    interspecies interaction between organisms GO:0044419 IDA
    reactive oxygen species metabolic process GO:0072593 ISS
    oxidation-reduction process GO:0055114 IEA
Subcellular Localization
    extracellular space GO:0005615 ISS
    cytoplasm GO:0005737 ISS
    dendrite cytoplasm GO:0032839 ISS
    cytosol GO:0005829 ISS
    extracellular matrix GO:0031012 ISS
    neuronal cell body GO:0043025 ISS
    mitochondrion GO:0005739 ISS
    cytoplasmic vesicle GO:0031410 ISS
    nucleus GO:0005634 ISS
    protein complex GO:0043234 ISS
    plasma membrane GO:0005886 ISS
 Experiment description of studies that identified SOD1 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SOD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SOD1 is involved
PathwayEvidenceSource
Detoxification of Reactive Oxygen Species IEA Reactome
Platelet degranulation IEA Reactome





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