Gene description for TBCD
Gene name tubulin folding cofactor D
Gene symbol TBCD
Other names/aliases -
Species Bos taurus
 Database cross references - TBCD
ExoCarta ExoCarta_281515
Entrez Gene 281515
UniProt Q28205  
 TBCD identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for TBCD
Molecular Function
    beta-tubulin binding GO:0048487 IDA
    GTPase activator activity GO:0005096 IDA
    protein binding GO:0005515 IPI
Biological Process
    adherens junction assembly GO:0034333 IDA
    protein folding GO:0006457 IDA
    post-chaperonin tubulin folding pathway GO:0007023 TAS
    tubulin complex biogenesis GO:0072668 IBA
    positive regulation of GTPase activity GO:0043547 IEA
    bicellular tight junction assembly GO:0070830 IDA
    negative regulation of cell-substrate adhesion GO:0010812 IDA
    microtubule cytoskeleton organization GO:0000226 IBA
    negative regulation of microtubule polymerization GO:0031115 IDA
Subcellular Localization
    adherens junction GO:0005912 IDA
    bicellular tight junction GO:0005923 IDA
    microtubule GO:0005874 IBA
    lateral plasma membrane GO:0016328 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified TBCD in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TBCD
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TBCD is involved
Post-chaperonin tubulin folding pathway IEA Reactome

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here