Gene description for TBCD
Gene name tubulin folding cofactor D
Gene symbol TBCD
Other names/aliases -
Species Bos taurus
 Database cross references - TBCD
ExoCarta ExoCarta_281515
Entrez Gene 281515
UniProt Q28205  
 TBCD identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for TBCD
Molecular Function
    beta-tubulin binding GO:0048487 IDA
    GTPase activator activity GO:0005096 IDA
    protein binding GO:0005515 IPI
Biological Process
    adherens junction assembly GO:0034333 IDA
    protein folding GO:0006457 IDA
    post-chaperonin tubulin folding pathway GO:0007023 TAS
    tubulin complex biogenesis GO:0072668 IBA
    positive regulation of GTPase activity GO:0043547 IEA
    bicellular tight junction assembly GO:0070830 IDA
    negative regulation of cell-substrate adhesion GO:0010812 IDA
    microtubule cytoskeleton organization GO:0000226 IBA
    negative regulation of microtubule polymerization GO:0031115 IDA
Subcellular Localization
    adherens junction GO:0005912 IDA
    bicellular tight junction GO:0005923 IDA
    microtubule GO:0005874 IBA
    lateral plasma membrane GO:0016328 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified TBCD in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TBCD
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TBCD is involved
PathwayEvidenceSource
Post-chaperonin tubulin folding pathway IEA Reactome





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