Gene description for TCN2
Gene name transcobalamin II
Gene symbol TCN2
Other names/aliases -
Species Bos taurus
 Database cross references - TCN2
ExoCarta ExoCarta_281518
Entrez Gene 281518
UniProt Q9XSC9  
 TCN2 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for TCN2
Molecular Function
    cobalamin binding GO:0031419 IDA
    metal ion binding GO:0046872 IEA
Biological Process
    cobalamin transport GO:0015889 IEA
    cobalt ion transport GO:0006824 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified TCN2 in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TCN2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TCN2 is involved
PathwayEvidenceSource
Cobalamin (Cbl, vitamin B12) transport and metabolism IEA Reactome





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