Gene description for THBS1
Gene name thrombospondin 1
Gene symbol THBS1
Other names/aliases THBS
Species Bos taurus
 Database cross references - THBS1
ExoCarta ExoCarta_281530
Entrez Gene 281530
UniProt Q28178  
 THBS1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
Serum 19327352    
 Gene ontology annotations for THBS1
Molecular Function
    heparin binding GO:0008201 IEA
    calcium ion binding GO:0005509 IEA
    extracellular matrix binding GO:0050840 IEA
Biological Process
    inflammatory response GO:0006954 IEA
    cell adhesion GO:0007155 IEA
    response to unfolded protein GO:0006986 IEA
    negative regulation of angiogenesis GO:0016525 IEA
    response to endoplasmic reticulum stress GO:0034976 ISS
    behavioral response to pain GO:0048266 ISS
Subcellular Localization
    extracellular space GO:0005615 IEA
    sarcoplasmic reticulum GO:0016529 ISS
    endoplasmic reticulum GO:0005783 ISS
 Experiment description of studies that identified THBS1 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 187
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19327352    
Organism Bos taurus
Experiment description Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes.
Authors Ochieng J, Pratap S, Khatua AK, Sakwe AM.
Journal name Exp Cell Res
Publication year 2009
Sample Serum
Sample name Normal - Fetal bovine serum
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for THBS1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which THBS1 is involved
No pathways found





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