Gene description for TLR2
Gene name toll-like receptor 2
Gene symbol TLR2
Other names/aliases -
Species Bos taurus
 Database cross references - TLR2
ExoCarta ExoCarta_281534
Vesiclepedia VP_281534
Entrez Gene 281534
UniProt Q95LA9  
 TLR2 identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for TLR2
Molecular Function
    transmembrane signaling receptor activity GO:0004888 IEA
    protein binding GO:0005515 IEA
    triacyl lipopeptide binding GO:0042497 IEA
Biological Process
    toll-like receptor signaling pathway GO:0002224 IEA
    inflammatory response GO:0006954 IEA
    immune response GO:0006955 IEA
Subcellular Localization
    membrane GO:0016020 IEA
 Experiment description of studies that identified TLR2 in sEVs
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TLR2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TLR2 is involved
PathwayEvidenceSource
Immune System IEA Reactome
Innate Immune System IEA Reactome
Neutrophil degranulation IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here