Gene description for EZR
Gene name ezrin
Gene symbol EZR
Other names/aliases VIL2
Species Bos taurus
 Database cross references - EZR
ExoCarta ExoCarta_281574
Entrez Gene 281574
UniProt P31976  
 EZR identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for EZR
Molecular Function
    actin filament binding GO:0051015 ISS
    poly(A) RNA binding GO:0044822 IEA
    cell adhesion molecule binding GO:0050839 ISS
Biological Process
    membrane to membrane docking GO:0022614 IEA
    actin filament bundle assembly GO:0051017 ISS
    positive regulation of gene expression GO:0010628 IEA
    establishment of endothelial barrier GO:0061028 IEA
    regulation of cell shape GO:0008360 IEA
    microvillus assembly GO:0030033 IEA
    establishment or maintenance of apical/basal cell polarity GO:0035088 ISS
    receptor internalization GO:0031623 IEA
    leukocyte cell-cell adhesion GO:0007159 IEA
Subcellular Localization
    microvillus membrane GO:0031528 ISS
    focal adhesion GO:0005925 IEA
    apical part of cell GO:0045177 ISS
    extracellular exosome GO:0070062 IEA
    extracellular space GO:0005615 IEA
    uropod GO:0001931 ISS
    cytosol GO:0005829 IEA
    actin cytoskeleton GO:0015629 ISS
    filopodium GO:0030175 IEA
    nucleolus GO:0005730 IEA
    basolateral plasma membrane GO:0016323 ISS
    apical plasma membrane GO:0016324 ISS
    cell cortex GO:0005938 IEA
    ciliary basal body GO:0036064 ISS
    actin filament GO:0005884 ISS
    ruffle membrane GO:0032587 IEA
    extrinsic component of membrane GO:0019898 ISS
 Experiment description of studies that identified EZR in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for EZR
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which EZR is involved
PathwayEvidenceSource
Netrin-1 signaling IEA Reactome
Recycling pathway of L1 IEA Reactome





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