Gene description for ANXA4
Gene name annexin A4
Gene symbol ANXA4
Other names/aliases -
Species Bos taurus
 Database cross references - ANXA4
ExoCarta ExoCarta_281625
Entrez Gene 281625
UniProt P13214  
 ANXA4 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for ANXA4
Molecular Function
    calcium ion binding GO:0005509 IEA
    carbohydrate binding GO:0030246 TAS
    NF-kappaB binding GO:0051059 IEA
    calcium-dependent phospholipid binding GO:0005544 IEA
    heparin binding GO:0008201 IDA
    identical protein binding GO:0042802 IPI
    calcium-dependent protein binding GO:0048306 IPI
    chondroitin sulfate binding GO:0035374 IDA
Biological Process
    regulation of transcription from RNA polymerase II promoter GO:0006357 IEA
    negative regulation of interleukin-8 secretion GO:2000483 IEA
    negative regulation of NF-kappaB transcription factor activity GO:0032088 IEA
    epithelial cell differentiation GO:0030855 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IEA
    cell surface GO:0009986 IEA
    apical plasma membrane GO:0016324 TAS
    nuclear membrane GO:0031965 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
    nucleus GO:0005634 IDA
    chromaffin granule membrane GO:0042584 IDA
    cytosol GO:0005829 IDA
    membrane GO:0016020 IDA
 Experiment description of studies that identified ANXA4 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ANXA4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ANXA4 is involved
No pathways found





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