Gene description for CAPN1
Gene name calpain 1, (mu/I) large subunit
Gene symbol CAPN1
Other names/aliases -
Species Bos taurus
 Database cross references - CAPN1
ExoCarta ExoCarta_281661
Entrez Gene 281661
UniProt Q27970  
 CAPN1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for CAPN1
Molecular Function
    calcium-dependent cysteine-type endopeptidase activity GO:0004198 ISS
    calcium ion binding GO:0005509 IEA
Biological Process
    proteolysis GO:0006508 ISS
    receptor catabolic process GO:0032801 IEA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    focal adhesion GO:0005925 IEA
    plasma membrane GO:0005886 IEA
    extracellular exosome GO:0070062 IEA
    cytosol GO:0005829 IEA
 Experiment description of studies that identified CAPN1 in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CAPN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CAPN1 is involved
Degradation of the extracellular matrix IEA Reactome

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