Gene description for CRYAB
Gene name crystallin, alpha B
Gene symbol CRYAB
Other names/aliases -
Species Bos taurus
 Database cross references - CRYAB
ExoCarta ExoCarta_281719
Entrez Gene 281719
UniProt P02510  
 CRYAB identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for CRYAB
Molecular Function
    metal ion binding GO:0046872 IEA
    protein homodimerization activity GO:0042803 ISS
    structural constituent of eye lens GO:0005212 IEA
    unfolded protein binding GO:0051082 IEA
Biological Process
    protein homooligomerization GO:0051260 IEA
    apoptotic process involved in morphogenesis GO:0060561 IEA
    response to hypoxia GO:0001666 IEA
    negative regulation of gene expression GO:0010629 IEA
    lens development in camera-type eye GO:0002088 IEA
    negative regulation of intracellular transport GO:0032387 ISS
    muscle organ development GO:0007517 IEA
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 IEA
    negative regulation of apoptotic process GO:0043066 ISS
    tubulin complex assembly GO:0007021 IEA
    cellular response to gamma radiation GO:0071480 IEA
    response to hydrogen peroxide GO:0042542 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IEA
    plasma membrane GO:0005886 IEA
    mitochondrion GO:0005739 IEA
    Z disc GO:0030018 IEA
    cytoplasm GO:0005737 ISS
    nucleus GO:0005634 ISS
    cytosol GO:0005829 IEA
 Experiment description of studies that identified CRYAB in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CRYAB
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CRYAB is involved
No pathways found





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