Gene description for GNAO1
Gene name guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Gene symbol GNAO1
Other names/aliases -
Species Bos taurus
 Database cross references - GNAO1
ExoCarta ExoCarta_281792
Vesiclepedia VP_281792
Entrez Gene 281792
UniProt P08239  
 GNAO1 identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for GNAO1
Molecular Function
    GTPase activity GO:0003924 IEA
    GTP binding GO:0005525 IEA
    G-protein beta/gamma-subunit complex binding GO:0031683 IEA
    G protein-coupled serotonin receptor binding GO:0031821 IEA
    mu-type opioid receptor binding GO:0031852 IEA
    corticotropin-releasing hormone receptor 1 binding GO:0051430 IEA
Biological Process
    adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 IEA
    G protein-coupled dopamine receptor signaling pathway GO:0007212 IEA
Subcellular Localization
    heterotrimeric G-protein complex GO:0005834 IEA
 Experiment description of studies that identified GNAO1 in sEVs
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GNAO1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which GNAO1 is involved
PathwayEvidenceSource
Beta-catenin independent WNT signaling IEA Reactome
Ca2+ pathway IEA Reactome
Signal Transduction IEA Reactome
Signaling by WNT IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here